@article {La Joiee282作者= {Renaud La乐趣Alexandre Bejanin和安妮·m·费根Nagehan Ayakta苏珊娜·l·贝克和维克多利亚Bourakova亚当·l·拳击手和Jungho Cha和安娜Karydas和吉娜杰罗姆和安妮马斯河和阿什利犯罪和扎卡里·a·米勒和詹姆斯p O {\ textquoteright}尼尔和朱莉范教授霍华德·j·罗森和理查德·蔡艾德丽安诉Visani和布鲁斯·l·米勒和William j . Jagust和吉尔·d·Rabinovici}, title = {[18 f] AV1451τ宠物之间的关联和CSF措施τ病理的临床样本},体积={90}={4},页面= {e282——e290} = {2018}, doi = {10.1212 / WNL。出版商0000000000004860}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的评估τ的流体和成像生物标记物之间的关系在临床病理和比较他们的诊断效用异类样首页本。方法对53例(28与临床阿尔茨海默病(AD)和25 non-AD临床神经退行性诊断)接受β-amyloid (Aβ)和τ([18 f] AV1451)宠物和腰椎穿刺。脑脊液生物标志物(Aβ42,总τ(t-tau),和磷酸化τ[p-tau])是衡量multianalyte免疫测定(AlzBio3)。接收机算子特性分析比较歧视non-AD Aβ-positive广告的条件在生物标记。脑脊液生物标记和宠物之间的相关性标准摄入值比率(SUVR)评估使用跳过皮尔森相关系数。Voxelwise分析运行评估区域CSF {\ textendash}宠物协会。结果[18 f] AV1451-PET皮质SUVR p-tau显示,优秀的Aβ-positive广告之间的歧视和non-AD条件(曲线下的面积0.92 {\ textendash} 0.94;为其他CSF措施)< = 0.83,达到83 \ %分类协议。在完整的样例中,皮质[18 f] AV1451与脑脊液生物标记,最强烈p-tau t-tau (r = 0.75 vs 0.57和-0.49 Aβ42)。限制患者Aβ-positive广告时,[18 f] AV1451 SUVR相关适度p-tau和t-tau (r = 0.46)但不是Aβ42 (r = 0.02)。voxelwise分析,[18 f] AV1451与CSF p-tau颞顶在内侧前额叶皮质和t-tau地区。 Within AD, Mini-Mental State Examination scores were associated with [18F]AV1451-PET, but not CSF biomarkers.Conclusion [18F]AV1451-PET and CSF p-tau had comparable value for differential diagnosis. Correlations were robust in a heterogeneous clinical group but attenuated (although significant) in AD, suggesting that fluid and imaging biomarkers capture different aspects of tau pathology.Classification of evidence This study provides Class III evidence that, in a clinical sample of patients with a variety of suspected neurodegenerative diseases, both CSF p-tau and [18F]AV1451 distinguish AD from non-AD conditions.Aβ=β-amyloid; AD=Alzheimer disease; AUC=area under the curve; CI=confidence interval; GM=gray matter; LBNL=Lawrence Berkeley National Laboratory; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; p-tau=phosphorylated tau; PHF-tau=paired helical filaments of tau; PiB=Pittsburgh compound B; ROC=receiver operating characteristic; SPM12=Statistical Parametric Mapping 12; SUVR=standard uptake value ratio; t-tau=total tau; UCSF=University of California San Francisco}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/90/4/e282}, eprint = {//www.ez-admanager.com/content/90/4/e282.full.pdf}, journal = {Neurology} }