TY - T1的帕金森症的早期体重预测差结果JF -神经学乔-神经病学SP - 2254 LP - 2261 - 10.1212 / WNL。首页0000000000004691六世- 89 - 22 AU -克里斯汀•卡明非盟-安格斯·d·麦克劳德盟Phyo k .敏盟——卡尔·e·Counsell Y1 - 2017/11/28 UR - //www.ez-admanager.com/content/89/22/2254.abstr首页act N2 -目的:比较体重随时间变化在帕金森病(PD)患者,那些非典型帕金森症,和匹配控制;确定影响减肥基线因素在帕金森症;检查它是否预测差的结果。方法:我们分析了帕金森症发病率的数据在苏格兰东北部(松树)研究中,一个事件,基于人群的前瞻性群组的帕金森患者和年龄,sex-matched控制年随访。混合模型分析描述PD患者体重变化,那些非典型帕金森症,和控制。持续的临床基线因素显著减肥(从基线的在5%的损失)和早期持续减肥和死亡之间的关联,痴呆,在帕金森症和依赖与Cox回归分析进行了研究。结果:共有515名参与者(与PD 240控制,187年,88年与非典型帕金森症)的平均随访5年。在诊断、非典型帕金森患者身体重量低于PD患者比对照组轻。PD患者体重比管控更迅速,和减肥最快在典型的帕金森症。多变量调整了潜在的混杂因素后,只有年龄是独立与持续的临床重要的减肥(危险比[HR] 10年期年龄增加1.83,95%可信区间[CI] 1.44 - -2.32)。 Weight loss occurring within 1 year of diagnosis was independently associated with increased risk of dependency (HR 2.11, 95% CI 1.00–4.42), dementia (HR 3.23, 95% CI 1.40–7.44), and death (HR 2.23, 95% CI 1.46–3.41).Conclusion: Weight loss occurs in early parkinsonism and is greater in atypical parkinsonism than in PD. Early weight loss in parkinsonism has prognostic significance, and targeted dietary interventions to prevent it may improve long-term outcomes.CI=confidence interval; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders, 4th edition; HR=hazard ratio; PD=Parkinson disease; PINE=Parkinsonism Incidence in North-East Scotland ER -