PT -期刊文章AU -约翰·f·Kurtzke TI -流行病学贡献多发性硬化症援助- 10.1212 / WNL.30.7_Part_2.61 DP - 1980 7月01第六TA -神经病学PG - 61 - 79 - 30第2部分IP - 7 4099 - http://n.neurology.首页org/content/30/7_Part_2/61.short 4100 - //www.ez-admanager.com/content/30/7_Part_2/61.full所以Neurology1980 7月01;30 AB -地理位置,多发性硬化症(MS)似乎分布分为三个地区的高,中,低频率。高频区域,患病率超过30每100000人口,包括北纬65°、45°之间的欧洲,加拿大和美国北部,南部和新西兰和澳大利亚南部。这些区域是有界区域的中频与100000年5至25 /患病率,包括欧洲南部、美国南部,澳大利亚。亚洲和非洲的地区(除了一个白色集团在南非)都低,每100000人口患病率在5。所有高收入和中等风险领域是白人为主的人群:在美国,黑人和东方人有低得多的利率比白人女士但仍然证明了地理梯度发现白人。迁移的研究表明,从整体来看,移民保留的风险他们的出生地。然而,这种风险显然不是出生时定义的:移民的死亡率女士出生在在另一个地区,死亡风险率特性之间的中间的出生地。患病率研究从高到低风险地区的移民表明青春期的年龄为风险自留是至关重要的;这些迁移在15岁获得他们的新住宅的风险降低。 Furthermore, several low-to-high studies show that those migrating in childhood or adolescence increase the risk of MS. The migrant data, plus the geographic distributions, serve to define MS as an acquired, exogenous (environmental) disease whose acquisition in ordinary circumstances takes place years before clinical onset. The data fit best the “simple” or “prevalence” hypothesis: that the cause of MS will be found where the clinical disease is common. Further evidence for this viewpoint is provided by the occurrence of two epidemics of MS: one (definite) in the Faroe Islands, the other (probable) in Iceland. Both followed the occupation of those lands by British forces during World War II. If this relation is causal, MS is not only acquired but also transmittable.