%PDF-1.6
%
103 0 obj
<>
endobj
87 0 obj
<>stream
Acrobat Distiller 7.0 (Windows)
10th June 2015
2023-05-15T05:18:08-07:00
0-00-00T20:15:00Z
Arbortext Advanced Print Publisher 9.1.510/W Unicode
2023-05-15T05:18:08-07:00
application/pdf
NEUROLOGY2014621029 29..39
uuid:d0f3fd8c-9535-4de8-844a-1bc2ab6d0834
uuid:5229ec36-1dd2-11b2-0a00-6a00f892d2ff
endstream
endobj
93 0 obj
<>
endobj
30 0 obj
<>
endobj
17 0 obj
<>
endobj
4 0 obj
<>
endobj
91 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
144 0 obj
<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/Type/Page>>
endobj
146 0 obj
[153 0 R 154 0 R 155 0 R 156 0 R 157 0 R 158 0 R 159 0 R 160 0 R 161 0 R 162 0 R 163 0 R 164 0 R 165 0 R 166 0 R]
endobj
147 0 obj
<>stream
q
192 0 0 51 237 695 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
12 0 0 12 236.50809 606.99988 Tm
(DOI 10.1212/WNL.0000000000001706)Tj
-1.63899 1 Td
(2015;85;29-39 Published Online before print May 29, 2015)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
/T1_0 1 Tf
1.63951 1.00001 Td
(Ludwig Kappos, Ernst-Wilhelm Radue, Giancarlo Comi, et al. )Tj
/T1_2 1 Tf
10.91549 1 Td
(RRMS)Tj
-16.84795 1 Td
(Switching from natalizumab to fingolimod: A randomized, placebo-controll\
ed study in)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 214.17004 580 Tm
(This information is current as of May 29, 2015)Tj
ET
108 261 450 311 re
0 0 m
S
BT
/T1_2 1 Tf
10 0 0 10 118 542.99997 Tm
(Services)Tj
0 1 TD
(Updated Information &)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 436.72974 542.99997 Tm
( )Tj
0 0 1 rg
-16.97297 0 Td
(http://n.neurology.org/content/85/1/29.full)Tj
0 g
T*
(including high resolution figures, can be found at:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 520 Tm
(Supplementary Material)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 303.39005 439.99976 Tm
( )Tj
0 0 1 rg
-3.639 0 Td
(706.DC4)Tj
T*
(http://n.neurology.org/content/suppl/2015/07/03/WNL.0000000000001)Tj
0 g
3.639 1.00001 Td
( )Tj
0 0 1 rg
-3.639 0 Td
(706.DC1)Tj
T*
(http://n.neurology.org/content/suppl/2015/05/29/WNL.0000000000001)Tj
0 g
3.639 1 Td
( )Tj
0 0 1 rg
-3.639 0 Td
(706.DC3)Tj
0 1.00001 TD
(http://n.neurology.org/content/suppl/2015/05/29/WNL.0000000000001)Tj
0 g
3.639 1 Td
( )Tj
0 0 1 rg
-3.639 0 Td
(706.DC2)Tj
0 1 TD
(http://n.neurology.org/content/suppl/2015/05/29/WNL.0000000000001)Tj
0 g
T*
(Supplementary material can be found at: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 422 Tm
(References)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 476.71951 411.99997 Tm
( )Tj
0 0 1 rg
-20.97195 0 Td
(http://n.neurology.org/content/85/1/29.full#ref-list-1)Tj
0 g
T*
(This article cites 22 articles, 6 of which you can access for free at: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 394 Tm
(Citations)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 496.15967 383.99997 Tm
( )Tj
0 0 1 rg
-22.91597 0 Td
(http://n.neurology.org/content/85/1/29.full##otherarticles)Tj
0 g
T*
(This article has been cited by 4 HighWire-hosted articles: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 366 Tm
(Subspecialty Collections)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 487.55997 335.99991 Tm
( )Tj
0 0 1 rg
-22.056 0 Td
(http://n.neurology.org/cgi/collection/multiple_sclerosis)Tj
0 g
/T1_2 1 Tf
T*
(Multiple sclerosis)Tj
/T1_0 1 Tf
0 1.00001 TD
(following collection\(s\): )Tj
0 1 TD
(This article, along with others on similar topics, appears in the)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 307.99997 Tm
(\240 )Tj
/T1_2 1 Tf
T*
(Permissions & Licensing)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 524.7699 297.99994 Tm
( )Tj
0 0 1 rg
-25.77699 0 Td
(http://www.neurology.org/about/about_the_journal#permissions)Tj
0 g
T*
(its entirety can be found online at:)Tj
0 1.00001 TD
(Information about reproducing this article in parts \(figures,tables\) o\
r in)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 269.99997 Tm
(\240 )Tj
/T1_2 1 Tf
0 1 TD
(Reprints)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 441.4299 269.99997 Tm
( )Tj
0 0 1 rg
-17.44299 0 Td
(http://n.neurology.org/subscribers/advertise)Tj
0 g
T*
(Information about ordering reprints can be found online:)Tj
ET
108 209 450 46 re
0 0 m
S
BT
/T1_0 1 Tf
10 0 0 10 113 216.99994 Tm
(rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X.)Tj
T*
(1951, it is now a weekly with 48 issues per year. Copyright \251 2015 Am\
erican Academy of Neurology. All )Tj
4.47202 1.00001 Td
(\256 is the official journal of the American Academy of Neurology. Publi\
shed continuously since)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
ET
q
246.75 0 0 77.25 209.625 113.75 cm
-1 TL /Im1 Do
Q
endstream
endobj
151 0 obj
<>stream
y]Cz+z]zk+ y܉7 zۉ6+ k]z ʸykzCyzyz zPl + z y z y z zk k 6 z]C+ z]C6 7Oz ] ʁO 6ʩzO ]ʁ ]C yl ]ʁ C 6 ʹk k z 6 l k C ] ]]B + ۹ z 6 ʁz C k 6 z ] Bz ʻz ]y 6+ y z ] O z y y y y * z z ʾ B z + C z 6 yz ] z6z P6 z C z + By Bz Bz 7]z P zy6] ]y y CC y y B7 y z zy C zz ^ PB ! y y y BkyC+B C 7 B zz O+C C 7B zz ]] B^ O Czz ^CBCBCP B B C ] B z y 6 B y B6 z Cz y ] 6 B C zz 66 zl B C zy z C Czy BzBk C z y zy C ] + C zz CO z B6 7 C zz z y6 C+ BBz6 zy +P*z C ]CzC z z ] C* B k B ykBC6+BClyʈ6 l+k] zʉPC6Oʩy^BC6 CBPz y zBCB 6ClyʙzBC7+BCPz ] C7z C B zk6 7zۙ]+ O ^ z+ yʉC 7k y ]+ +^ۉP 6]ۂ ] z C k C z] 6lC +zB+] zy ]k+ ^ z O 7C 6kCBC]zyz yzyz]BC PCz zyzCBCk+ ʹ6 C] B zB zyz^BC+ BzyzPC 7 C y kC + z ] ]+ 6 ] k C C B zB + ] B B zC + +z ] ]* zz B z6 ]k+ C6 ! C zP kC ] + z k+ + z] kC P z C y ^ B 6 C z 7kʹ]+ 7 C z ] yP BPBzzO O z +]ʹl7 + ]l+ ] + lBCPC 6 C z ]+] + z z C y* +O z B ]z k kzC zP+ CkzkB Bk B ]C z7+C ] z] y ^ Bz z Py 6]6 k+ Pz+ ] B ] Bz+! ^ 6y z* y l B6 C ] z P ! ] ] B 7 7 C By!B] B6 z C ]]C k+]6 6 z] 6 ] ] C6 kO C ] Cy lB6 z6 C+ 7 ]6 y ] 6 z 6 O+ z ] C] B y+ z CP 6zy CC lO Cz ]* z P y 6C7 Bz7 ]]6 z P B 6+ O6 ^ y ] + k C ۷ B7 B z ^ z z C ] 7+ z ^ 7 ] + B 7 Cy ]^ z BC ]] C P z O 6 ] C y ] k O C 7C y 6 7 ! z C +kCBy ] O + z C k + O C OB y C B y B k y O z l k BC B ]Cz P C k zB B B l y z ^O ^ C +B k l C z+ + C yCB P C z ! lz B 6 B C ] By z + zBB C ! Py z z C B C] CB 6 B z k6 zB BB y B y B ] O z+ C y B6 B z y zz7 y BCC ] z ^ O P C+ 6+ B C Cz* kyzyzyzylCBCBC z C CCz ] Pz 7 z Ck C B z zB C B 7 + z y 6 k Cl ] C B 6C zC zB B B C k z + z +z B 7+ C 6 B z C z C CB C O 7 6z 6 ] C yC C z ]B y l zB C C C k y ] y k C B l+ C ] ] Cz 6 O y B BBP P y + 6B ] O C C P Bz +kz yz yzyz yzyzyzyz z B CB z O ^ z O C z C C6 Bz + yC CB y 6z z z C C ] 7 B* B yk z z B B B z y B k z P ] ] C C z 6 yB C B z C +z O z z + C B z y B C Cz lC B z C B O +] B Cy zC B C yB Cz yz z + + B 7C z zB C B y+ z z zy l C]6Cz zy yCCB z y By y 6 O k C P 6 OC+ B ] PB y] y zC B Cy y C z] C+ B6 ] ByC zz BC B y z B z BC * ] + C6 ] B y C] y BB C z y C z B ^ ]+O] 6 z C C z 6 B yC CC y y Cy B y + z +y B y + y C B Cz y C z C z ] z *z Cz yB B C y k Cz Bz ! O O k 6 y Cz z B B C z C O y C z C Cyz z B y z z C C B z C y z B z P k + z y ] C y P y B C B z + zz ] z 6 +] y z C B y C zC BCz z yyO B ]] y7 zB y C C C z+ z z k C ]*!+ B ] z zz + zC ] y B CC z B z CCy6 *ۙ6 z z z z C B B yk z 6y P C]z]C+C z z y y BB B z O z ]z ! ] P + P z C z C C C z +] zB 6C k z C y yC CB y ! C z y k k k+y + + B z ] z 6 C z C CBy O 6y + z C +ll+ ]C y ^ y k z B B C z P k z C CB* 6Cz + ۢC y6 z 6 ] B C C y z ] ! ] P ܸ 6 ] ] P6z B C B B z O ] 6z 6 + ۡ C z P 6 B B B y O * z+ + 6ʩ z]B z 6 6 C y zy kC 6P*+ ۡ z ] C y z yk zy + * ] z y zy B y !+ z y ʠ ʸ ]y C+ C 7 C z y y + + + ] ] B ] y ^ z+ C+C* C + z z ]ʣ y y6 z ]6] z C z y + B O6 + C C ]6 y y 77^y * B P C k y l B l 6 7 z+ z+ k6 l B 76 ] k * O B C z + 6 6 k+ B 6 z k6 + y k +B B 6 + O 6 z 6 O * l O z6 ]] ] y ] ] P 6+ + ۳] y Ckl+ kz C l] ]67 C 6 + ] 7 B O ^ yO z]7y ] C 666 6ʣ k O+6 B 6kzC+ O l P] ] C P ] ʉB ]۷ C+ k k 6 ]+ + +]6 O^k Oz zyzy]CB Cz y۹zBC 6CPz C6 67 BB ʨy]B+CBz y + +B CzlC+ 6Pz k ]] + By B + B y ] C ]k CyP ] + *]k+ P ^ ] z ] kB6 *!!zC y C ] Py + O Cy C P B z+ z C Clz + C B] +6 O z] z7+z+ zl zC 6k 7B ] 6 l] +6 z ܧy!CBPzyz yz CBCB+6 P 6P P C Cz76C^zyz z yz yzyOCBC6 k+ 6 CBC]yzyz z yzykCBC*+P ]6 k ] +O B܈6 O C +kyC +Oۥ]+ CyP Bہ k ʨyPB* 6BkyPC+7Bk C+lʕʘyBC+CB]y۹z]BC +By Py O]z 6 ] ^ہ6 BC + 6 ] CPyz yzyz yz kC 6 6lۨl+ O z6C] ++6 z] 6 C 6 7 lz6 C ] 6y B z 7 l C] ہ B ] ]]C ] ہ C ] B C ] 6z C! CB l 7 B z +C C z P z* B P z B B P B B ] z ! + ]Bk^ ہ Oz ] ]+ y+ B ]C O Ck y k ] 7 7] + ] 7 ] ] z P ]B z] 6 6 zB6 ] y6 ^ ہ] O] y C 6kʨzCB C 7B 6CBCBCB ʁ ] ] + ʁ ] +ʁC ]B z+ +]CB]C +kʁl76zʁۘ]6 +Pzʹy ]CBCkzy
endstream
endobj
152 0 obj
<>/Filter/FlateDecode/Height 309/Length 29240/Name/X/Subtype/Image/Type/XObject/Width 987>>stream
H?Hi)B@HsPp#R$cHۜZZ%VVSeK<PX Ā"!!r70d>:S=3y۷}7b @Ҿ B<M3?2{ %ȣٜZ* JkӥZ nw;