%PDF-1.4
%
63 0 obj
<>
endobj
156 0 obj
<>stream
Acrobat Distiller 7.0 (Windows)
1th April 2015
2023-05-12T09:16:11-07:00
0-00-00T20:15:00Z
Arbortext Advanced Print Publisher 9.1.510/W Unicode
2023-05-12T09:16:11-07:00
application/pdf
NEUROLOGY2014617068 1805..1815
uuid:ead86726-9d1f-4ba3-ab2c-02df2d4ddaff
uuid:9e5789c6-1dd1-11b2-0a00-1e00284498ff
1th April 2015
endstream
endobj
55 0 obj
<>
endobj
57 0 obj
<>
endobj
58 0 obj
<>
endobj
59 0 obj
<>
endobj
38 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36.0 36.0 630.0 819.0]/Type/Page>>
endobj
157 0 obj
<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/Type/Page>>
endobj
159 0 obj
[166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R]
endobj
160 0 obj
<>stream
q
192 0 0 51 237 696 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
12 0 0 12 236.50809 619.99991 Tm
(DOI 10.1212/WNL.0000000000001520)Tj
-2.52798 1 Td
(2015;84;1805-1815 Published Online before print April 3, 2015)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
/T1_0 1 Tf
2.44699 1.00001 Td
(Brian G. Weinshenker, Gerard Barron, Jacinta M. Behne, et al. )Tj
/T1_2 1 Tf
-4.47699 1 Td
(Challenges and opportunities in designing clinical trials for neuromyeli\
tis optica)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 215.16605 593 Tm
(This information is current as of April 3, 2015)Tj
ET
108 302 450 283 re
0 0 m
S
BT
/T1_2 1 Tf
10 0 0 10 118 555.99997 Tm
(Services)Tj
0 1 TD
(Updated Information &)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 451.72974 555.99997 Tm
( )Tj
0 0 1 rg
-18.47297 0 Td
(http://n.neurology.org/content/84/17/1805.full)Tj
0 g
T*
(including high resolution figures, can be found at:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 533 Tm
(Supplementary Material)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 303.39005 512.99994 Tm
( )Tj
0 0 1 rg
-3.639 0 Td
(520.DC1)Tj
T*
(http://n.neurology.org/content/suppl/2015/04/03/WNL.0000000000001)Tj
0 g
0 1.00001 TD
(Supplementary material can be found at: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 495 Tm
(References)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 491.71951 484.99997 Tm
( )Tj
0 0 1 rg
-22.47195 0 Td
(http://n.neurology.org/content/84/17/1805.full#ref-list-1)Tj
0 g
0 1 TD
(This article cites 54 articles, 16 of which you can access for free at: \
)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 467 Tm
(Subspecialty Collections)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 484.7699 376.99973 Tm
( )Tj
0 0 1 rg
-21.77699 0 Td
(http://n.neurology.org/cgi/collection/devics_syndrome)Tj
0 g
/T1_2 1 Tf
T*
(Devic's syndrome)Tj
/T1_0 1 Tf
3.611 1.00001 Td
( )Tj
0 0 1 rg
-3.611 0 Td
(_design_)Tj
T*
(http://n.neurology.org/cgi/collection/clinical_trials_methodology_study)Tj
0 g
/T1_2 1 Tf
T*
(Clinical trials Methodology/study design)Tj
/T1_0 1 Tf
1.33301 1.00001 Td
( )Tj
0 0 1 rg
-1.33301 0 Td
(ues)Tj
T*
(http://n.neurology.org/cgi/collection/all_ethics_in_neurology_legal_iss)Tj
0 g
/T1_2 1 Tf
T*
(All Ethics in Neurology/Legal issues)Tj
/T1_0 1 Tf
T*
(following collection\(s\): )Tj
0 1.00001 TD
(This article, along with others on similar topics, appears in the)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 348.99997 Tm
(\240 )Tj
/T1_2 1 Tf
0 1 TD
(Permissions & Licensing)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 524.7699 338.99994 Tm
( )Tj
0 0 1 rg
-25.77699 0 Td
(http://www.neurology.org/about/about_the_journal#permissions)Tj
0 g
T*
(its entirety can be found online at:)Tj
0 1.00001 TD
(Information about reproducing this article in parts \(figures,tables\) o\
r in)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 310.99997 Tm
(\240 )Tj
/T1_2 1 Tf
0 1 TD
(Reprints)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 441.4299 310.99997 Tm
( )Tj
0 0 1 rg
-17.44299 0 Td
(http://n.neurology.org/subscribers/advertise)Tj
0 g
T*
(Information about ordering reprints can be found online:)Tj
ET
108 209 450 46 re
0 0 m
S
BT
/T1_0 1 Tf
10 0 0 10 113 216.99994 Tm
(rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X.)Tj
T*
(1951, it is now a weekly with 48 issues per year. Copyright \251 2015 Am\
erican Academy of Neurology. All )Tj
4.47202 1.00001 Td
(\256 is the official journal of the American Academy of Neurology. Publi\
shed continuously since)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
ET
q
246.75 0 0 77.25 209.625 113.75 cm
-1 TL /Im1 Do
Q
endstream
endobj
164 0 obj
<>stream
y]Cz+z]zk+ y܉7 zۉ6+ k]z ʸykzCyzyz zPl + z y z y z zk k 6 z]C+ z]C6 7Oz ] ʁO 6ʩzO ]ʁ ]C yl ]ʁ C 6 ʹk k z 6 l k C ] ]]B + ۹ z 6 ʁz C k 6 z ] Bz ʻz ]y 6+ y z ] O z y y y y * z z ʾ B z + C z 6 yz ] z6z P6 z C z + By Bz Bz 7]z P zy6] ]y y CC y y B7 y z zy C zz ^ PB ! y y y BkyC+B C 7 B zz O+C C 7B zz ]] B^ O Czz ^CBCBCP B B C ] B z y 6 B y B6 z Cz y ] 6 B C zz 66 zl B C zy z C Czy BzBk C z y zy C ] + C zz CO z B6 7 C zz z y6 C+ BBz6 zy +P*z C ]CzC z z ] C* B k B ykBC6+BClyʈ6 l+k] zʉPC6Oʩy^BC6 CBPz y zBCB 6ClyʙzBC7+BCPz ] C7z C B zk6 7zۙ]+ O ^ z+ yʉC 7k y ]+ +^ۉP 6]ۂ ] z C k C z] 6lC +zB+] zy ]k+ ^ z O 7C 6kCBC]zyz yzyz]BC PCz zyzCBCk+ ʹ6 C] B zB zyz^BC+ BzyzPC 7 C y kC + z ] ]+ 6 ] k C C B zB + ] B B zC + +z ] ]* zz B z6 ]k+ C6 ! C zP kC ] + z k+ + z] kC P z C y ^ B 6 C z 7kʹ]+ 7 C z ] yP BPBzzO O z +]ʹl7 + ]l+ ] + lBCPC 6 C z ]+] + z z C y* +O z B ]z k kzC zP+ CkzkB Bk B ]C z7+C ] z] y ^ Bz z Py 6]6 k+ Pz+ ] B ] Bz+! ^ 6y z* y l B6 C ] z P ! ] ] B 7 7 C By!B] B6 z C ]]C k+]6 6 z] 6 ] ] C6 kO C ] Cy lB6 z6 C+ 7 ]6 y ] 6 z 6 O+ z ] C] B y+ z CP 6zy CC lO Cz ]* z P y 6C7 Bz7 ]]6 z P B 6+ O6 ^ y ] + k C ۷ B7 B z ^ z z C ] 7+ z ^ 7 ] + B 7 Cy ]^ z BC ]] C P z O 6 ] C y ] k O C 7C y 6 7 ! z C +kCBy ] O + z C k + O C OB y C B y B k y O z l k BC B ]Cz P C k zB B B l y z ^O ^ C +B k l C z+ + C yCB P C z ! lz B 6 B C ] By z + zBB C ! Py z z C B C] CB 6 B z k6 zB BB y B y B ] O z+ C y B6 B z y zz7 y BCC ] z ^ O P C+ 6+ B C Cz* kyzyzyzylCBCBC z C CCz ] Pz 7 z Ck C B z zB C B 7 + z y 6 k Cl ] C B 6C zC zB B B C k z + z +z B 7+ C 6 B z C z C CB C O 7 6z 6 ] C yC C z ]B y l zB C C C k y ] y k C B l+ C ] ] Cz 6 O y B BBP P y + 6B ] O C C P Bz +kz yz yzyz yzyzyzyz z B CB z O ^ z O C z C C6 Bz + yC CB y 6z z z C C ] 7 B* B yk z z B B B z y B k z P ] ] C C z 6 yB C B z C +z O z z + C B z y B C Cz lC B z C B O +] B Cy zC B C yB Cz yz z + + B 7C z zB C B y+ z z zy l C]6Cz zy yCCB z y By y 6 O k C P 6 OC+ B ] PB y] y zC B Cy y C z] C+ B6 ] ByC zz BC B y z B z BC * ] + C6 ] B y C] y BB C z y C z B ^ ]+O] 6 z C C z 6 B yC CC y y Cy B y + z +y B y + y C B Cz y C z C z ] z *z Cz yB B C y k Cz Bz ! O O k 6 y Cz z B B C z C O y C z C Cyz z B y z z C C B z C y z B z P k + z y ] C y P y B C B z + zz ] z 6 +] y z C B y C zC BCz z yyO B ]] y7 zB y C C C z+ z z k C ]*!+ B ] z zz + zC ] y B CC z B z CCy6 *ۙ6 z z z z C B B yk z 6y P C]z]C+C z z y y BB B z O z ]z ! ] P + P z C z C C C z +] zB 6C k z C y yC CB y ! C z y k k k+y + + B z ] z 6 C z C CBy O 6y + z C +ll+ ]C y ^ y k z B B C z P k z C CB* 6Cz + ۢC y6 z 6 ] B C C y z ] ! ] P ܸ 6 ] ] P6z B C B B z O ] 6z 6 + ۡ C z P 6 B B B y O * z+ + 6ʩ z]B z 6 6 C y zy kC 6P*+ ۡ z ] C y z yk zy + * ] z y zy B y !+ z y ʠ ʸ ]y C+ C 7 C z y y + + + ] ] B ] y ^ z+ C+C* C + z z ]ʣ y y6 z ]6] z C z y + B O6 + C C ]6 y y 77^y * B P C k y l B l 6 7 z+ z+ k6 l B 76 ] k * O B C z + 6 6 k+ B 6 z k6 + y k +B B 6 + O 6 z 6 O * l O z6 ]] ] y ] ] P 6+ + ۳] y Ckl+ kz C l] ]67 C 6 + ] 7 B O ^ yO z]7y ] C 666 6ʣ k O+6 B 6kzC+ O l P] ] C P ] ʉB ]۷ C+ k k 6 ]+ + +]6 O^k Oz zyzy]CB Cz y۹zBC 6CPz C6 67 BB ʨy]B+CBz y + +B CzlC+ 6Pz k ]] + By B + B y ] C ]k CyP ] + *]k+ P ^ ] z ] kB6 *!!zC y C ] Py + O Cy C P B z+ z C Clz + C B] +6 O z] z7+z+ zl zC 6k 7B ] 6 l] +6 z ܧy!CBPzyz yz CBCB+6 P 6P P C Cz76C^zyz z yz yzyOCBC6 k+ 6 CBC]yzyz z yzykCBC*+P ]6 k ] +O B܈6 O C +kyC +Oۥ]+ CyP Bہ k ʨyPB* 6BkyPC+7Bk C+lʕʘyBC+CB]y۹z]BC +By Py O]z 6 ] ^ہ6 BC + 6 ] CPyz yzyz yz kC 6 6lۨl+ O z6C] ++6 z] 6 C 6 7 lz6 C ] 6y B z 7 l C] ہ B ] ]]C ] ہ C ] B C ] 6z C! CB l 7 B z +C C z P z* B P z B B P B B ] z ! + ]Bk^ ہ Oz ] ]+ y+ B ]C O Ck y k ] 7 7] + ] 7 ] ] z P ]B z] 6 6 zB6 ] y6 ^ ہ] O] y C 6kʨzCB C 7B 6CBCBCB ʁ ] ] + ʁ ] +ʁC ]B z+ +]CB]C +kʁl76zʁۘ]6 +Pzʹy ]CBCkzy
endstream
endobj
165 0 obj
<>/Filter/FlateDecode/Height 309/Length 29240/Name/X/Subtype/Image/Type/XObject/Width 987>>stream
H?Hi)B@HsPp#R$cHۜZZ%VVSeK<PX Ā"!!r70d>:S=3y۷}7b @Ҿ B<M3?2{ %ȣٜZ* JkӥZ nw;