我们同意,estimates-e.g的相对风险。,hazard ratios—in observational studies are unlikely to be comparable to estimates from clinical trials. Observational studies likely capture long term habits beyond the duration of randomized controlled trials (RCTs). Further, there is also the issue of residual confounding. We agree that the results of any observational study—even of high quality—cannot demonstrate causality. As the authors note, RCTs are expensive and time consuming. Perhaps the most important role of observational studies in the prevention of Alzheimer’s dementia is to suggest which of the many potential interventions appropriate to a wide population base most deserve rigorous examination in RCTs. We agree that causal loop diagrams deserve exploration as a means of doing so. We think strongly encouraging and funding both observational studies and RCTs of adequate size and design, however, is of greater importance in finding the best path to prevention of this common condition of dreadful impact on public health.
我们非常感谢评论最近的文章1Drs。Uleman和老Rikkert强调潜在的生活方式在阿尔茨海默氏痴呆预防的重要性。
我们同意,estimates-e.g的相对风险。,hazard ratios—in observational studies are unlikely to be comparable to estimates from clinical trials. Observational studies likely capture long term habits beyond the duration of randomized controlled trials (RCTs). Further, there is also the issue of residual confounding. We agree that the results of any observational study—even of high quality—cannot demonstrate causality. As the authors note, RCTs are expensive and time consuming. Perhaps the most important role of observational studies in the prevention of Alzheimer’s dementia is to suggest which of the many potential interventions appropriate to a wide population base most deserve rigorous examination in RCTs. We agree that causal loop diagrams deserve exploration as a means of doing so. We think strongly encouraging and funding both observational studies and RCTs of adequate size and design, however, is of greater importance in finding the best path to prevention of this common condition of dreadful impact on public health.
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