2022年8月23日
;99 (8)
金博宝手机版官网首页研究文章
开放获取
生理和心理活动,疾病易感性和痴呆的风险
基于英国生物库的前瞻性队列研究
第一次出版2022年7月27日,
DOI: https://doi.org/10.1212/WNL.0000000000200701
健胃朱
整形外科学系(J.Z.)、骨科研究所(J.Z.),全国老年病学临床研究中心(J.Z.),中国西部生物医学大数据中心(F.G.,Y.Z.,Y.Q.,H.Y.,H.S.), Division of Nephrology (W.C.), Kidney Research Institute (W.C.), State Key Laboratory of Biotherapy and Cancer Center (W.C.), and Department of Anesthesiology (L.Y.), West China Hospital, Sichuan University, Chengdu; Medical Big Data Center (F.G., Y.Z., Y.Q., H.Y., H.S.), Sichuan University, Chengdu, China; Institute of Environmental Medicine (F.F.), Karolinska Institute, Stockholm, Sweden; and Center of Public Health Sciences (H.S.), Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Fenfen通用电气
整形外科学系(J.Z.)、骨科研究所(J.Z.),全国老年病学临床研究中心(J.Z.),中国西部生物医学大数据中心(F.G.,Y.Z.,Y.Q.,H.Y.,H.S.), Division of Nephrology (W.C.), Kidney Research Institute (W.C.), State Key Laboratory of Biotherapy and Cancer Center (W.C.), and Department of Anesthesiology (L.Y.), West China Hospital, Sichuan University, Chengdu; Medical Big Data Center (F.G., Y.Z., Y.Q., H.Y., H.S.), Sichuan University, Chengdu, China; Institute of Environmental Medicine (F.F.), Karolinska Institute, Stockholm, Sweden; and Center of Public Health Sciences (H.S.), Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
曾于
整形外科学系(J.Z.)、骨科研究所(J.Z.),全国老年病学临床研究中心(J.Z.),中国西部生物医学大数据中心(F.G.,Y.Z.,Y.Q.,H.Y.,H.S.), Division of Nephrology (W.C.), Kidney Research Institute (W.C.), State Key Laboratory of Biotherapy and Cancer Center (W.C.), and Department of Anesthesiology (L.Y.), West China Hospital, Sichuan University, Chengdu; Medical Big Data Center (F.G., Y.Z., Y.Q., H.Y., H.S.), Sichuan University, Chengdu, China; Institute of Environmental Medicine (F.F.), Karolinska Institute, Stockholm, Sweden; and Center of Public Health Sciences (H.S.), Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
圆圆曲
整形外科学系(J.Z.)、骨科研究所(J.Z.),全国老年病学临床研究中心(J.Z.),中国西部生物医学大数据中心(F.G.,Y.Z.,Y.Q.,H.Y.,H.S.), Division of Nephrology (W.C.), Kidney Research Institute (W.C.), State Key Laboratory of Biotherapy and Cancer Center (W.C.), and Department of Anesthesiology (L.Y.), West China Hospital, Sichuan University, Chengdu; Medical Big Data Center (F.G., Y.Z., Y.Q., H.Y., H.S.), Sichuan University, Chengdu, China; Institute of Environmental Medicine (F.F.), Karolinska Institute, Stockholm, Sweden; and Center of Public Health Sciences (H.S.), Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
了雯雯陈
整形外科学系(J.Z.)、骨科研究所(J.Z.),全国老年病学临床研究中心(J.Z.),中国西部生物医学大数据中心(F.G.,Y.Z.,Y.Q.,H.Y.,H.S.), Division of Nephrology (W.C.), Kidney Research Institute (W.C.), State Key Laboratory of Biotherapy and Cancer Center (W.C.), and Department of Anesthesiology (L.Y.), West China Hospital, Sichuan University, Chengdu; Medical Big Data Center (F.G., Y.Z., Y.Q., H.Y., H.S.), Sichuan University, Chengdu, China; Institute of Environmental Medicine (F.F.), Karolinska Institute, Stockholm, Sweden; and Center of Public Health Sciences (H.S.), Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
华振杨
整形外科学系(J.Z.)、骨科研究所(J.Z.),全国老年病学临床研究中心(J.Z.),中国西部生物医学大数据中心(F.G.,Y.Z.,Y.Q.,H.Y.,H.S.), Division of Nephrology (W.C.), Kidney Research Institute (W.C.), State Key Laboratory of Biotherapy and Cancer Center (W.C.), and Department of Anesthesiology (L.Y.), West China Hospital, Sichuan University, Chengdu; Medical Big Data Center (F.G., Y.Z., Y.Q., H.Y., H.S.), Sichuan University, Chengdu, China; Institute of Environmental Medicine (F.F.), Karolinska Institute, Stockholm, Sweden; and Center of Public Health Sciences (H.S.), Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Lei杨
整形外科学系(J.Z.)、骨科研究所(J.Z.),全国老年病学临床研究中心(J.Z.),中国西部生物医学大数据中心(F.G.,Y.Z.,Y.Q.,H.Y.,H.S.), Division of Nephrology (W.C.), Kidney Research Institute (W.C.), State Key Laboratory of Biotherapy and Cancer Center (W.C.), and Department of Anesthesiology (L.Y.), West China Hospital, Sichuan University, Chengdu; Medical Big Data Center (F.G., Y.Z., Y.Q., H.Y., H.S.), Sichuan University, Chengdu, China; Institute of Environmental Medicine (F.F.), Karolinska Institute, Stockholm, Sweden; and Center of Public Health Sciences (H.S.), Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
方方
整形外科学系(J.Z.)、骨科研究所(J.Z.),全国老年病学临床研究中心(J.Z.),中国西部生物医学大数据中心(F.G.,Y.Z.,Y.Q.,H.Y.,H.S.), Division of Nephrology (W.C.), Kidney Research Institute (W.C.), State Key Laboratory of Biotherapy and Cancer Center (W.C.), and Department of Anesthesiology (L.Y.), West China Hospital, Sichuan University, Chengdu; Medical Big Data Center (F.G., Y.Z., Y.Q., H.Y., H.S.), Sichuan University, Chengdu, China; Institute of Environmental Medicine (F.F.), Karolinska Institute, Stockholm, Sweden; and Center of Public Health Sciences (H.S.), Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
欢的歌
整形外科学系(J.Z.)、骨科研究所(J.Z.),全国老年病学临床研究中心(J.Z.),中国西部生物医学大数据中心(F.G.,Y.Z.,Y.Q.,H.Y.,H.S.), Division of Nephrology (W.C.), Kidney Research Institute (W.C.), State Key Laboratory of Biotherapy and Cancer Center (W.C.), and Department of Anesthesiology (L.Y.), West China Hospital, Sichuan University, Chengdu; Medical Big Data Center (F.G., Y.Z., Y.Q., H.Y., H.S.), Sichuan University, Chengdu, China; Institute of Environmental Medicine (F.F.), Karolinska Institute, Stockholm, Sweden; and Center of Public Health Sciences (H.S.), Faculty of Medicine, University of Iceland, Reykjavík, Iceland.

文章数据和数据
数据
图2
小时的生理和心理活动的所有项目之间的关联和痴呆
*继续看电视被认为是一个变量。__小时来自Cox回归模型,调整年龄、性别、种族和民族,汤森剥夺指数、收入、体重指数、吸烟状况、酒精状态,Charlson发病率指数,历史的高血压、高脂血症的历史,和痴呆的家族病史。HR =风险比。
图3
身体活动之间的关联模式和任何或特定亚型的痴呆
独联体*小时和95%来自Cox回归模型,调整年龄、性别、种族和民族,汤森剥夺指数,教育、收入、体重指数、吸烟状况、酒精状态,Charlson发病率指数,历史的高血压、高脂血症的历史,和痴呆的家族病史。HR =风险比;IR =发生率;电脑=主成分;Ref =参考。
图4
心理活动之间的关联模式和任何或特定亚型的痴呆
独联体*小时和95%来自Cox回归模型,调整年龄、性别、种族和民族,汤森剥夺指数,教育、收入、体重指数、吸烟状况、酒精状态,Charlson发病率指数,历史的高血压、高脂血症的历史,和痴呆的家族病史。HR =风险比;IR =发生率;电脑=主成分;Ref =参考。
图5
生理和心理协会活动模式与痴呆个体易感性不同程度的疾病
独联体*小时和95%来自Cox回归模型,调整年龄、性别、种族和民族,汤森剥夺指数,教育、收入、体重指数、吸烟状况、酒精状态,Charlson发病率指数历史高血压和高脂血症的历史。HR =风险比;IR =发生率;电脑=主成分;PRS =多基因风险评分;Ref =参考。
图6
生理和心理协会活动模式与老年痴呆症患者和没有自我痴呆的家族病史
独联体*小时和95%来自Cox回归模型,调整年龄、性别、种族和民族,汤森剥夺指数,教育、收入、体重指数、吸烟状况、酒精状态,Charlson发病率指数历史高血压和高脂血症的历史。HR =风险比;IR =发生率;电脑=主成分;Ref =参考。
表
信:快速的网络通信
-
读者反应:生理和心理活动,疾病易感性和痴呆的风险:一项前瞻性群组研究基于英国生物库
- TomoyukiKawada,教授,日本医学院
2022年9月1日提交