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图 为PD预防试验药物候选人和他们的依据
可信的部分清单神经保护潜在的治疗药物,由它们的相对安全风险高低,对应于他们的地位repurposable药物(有广泛的安全数据)和新型药物(很少或没有人类安全数据)。近端列出了假定的神经保护作用机制,以及高危人群最合理有针对性的在这一点上基于多个证据(破碎的人类基因,流行病学,临床前模型)。的数量+迹象表明作者的主观印象的力量的证据在一个给定的类别,用括号反映更多的间接证据。✔表示支持证据毒素和/或基因PD的临床前模型。引用最近的研究(见参考文本)或相关的临床试验相关提议代理(=ACTRN12620000560998,b =NCT03905811c =NCT04386317d =NCT04777331,e =NCT02606682f =NCT04685265,g =NCT04483479h =NCT03655236我=NCT04127578j =审判NL7061 [NTR7299]])。αSyn =α-突触核蛋白;麻生太郎=反义寡核苷酸;考克斯=环氧酶;呃=延长释放;GCase =葡糖脑苷脂酶;非甾体抗炎药(非甾体类抗炎药;PD =帕金森病;PPAR-γ=过氧物酶体proliferator-activated受体γ;ProPD =前驱的PD; RBD = REM sleep behavior disorder.
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![Drug Candidates and Their Rationales for PD Prevention Trials Partial listing of plausibly neuroprotective potential therapeutic agents, organized by their relative safety risk into low and high, which corresponds to their status as repurposable drugs (for which there are extensive safety data) and novel drugs (for which there is little or no human safety data). Proximal mechanisms of putative neuroprotective action are listed, along with the at-risk population most rationally targeted at this point based on multiple lines of evidence (broken out to human genetic, epidemiologic, and preclinical models). The number of + signs indicates authors' subjective impression of the strength of evidence in a given category, with brackets reflecting more indirect evidence. ✔ indicates supportive evidence in toxin and/or genetic preclinical models of PD. Citations for most recent study (see text for reference) or associated clinical trial associated with proposed agents (a = ACTRN12620000560998, b = NCT03905811, c = NCT04386317, d = NCT04777331, e = NCT02606682, f = NCT04685265, g = NCT04483479, h = NCT03655236, i = NCT04127578, j = Trial NL7061 [NTR7299]]). αSyn = alpha-synuclein; ASO = antisense oligonucleotide; COX = cyclooxygenase; ER = extended release; GCase = glucocerebrosidase; NSAID = nonsteroidal anti-inflammatory drug; PD = Parkinson disease; PPAR-γ = peroxisome proliferator–activated receptor gamma; ProPD = prodromal PD; RBD = REM sleep behavior disorder.](http://www.ez-admanager.com/content/neurology/99/7_Supplement_1/34/F1.large.jpg?width=800&height=600&carousel=1){kind=link}
