特征的视网膜神经纤维层厚度在一群与谷氨酸脱羧酶65和甘氨酸受体自身免疫
文摘
客观的描述视网膜神经纤维层(RNFL)患者的人口统计学和临床资料的谷氨酸脱羧酶65 (GAD65)和甘氨酸受体(GlyR)神经系统自身免疫性。
背景GAD65和GlyR自身免疫可能导致广泛的临床现象,包括stiff-person谱系障碍(SPSD)和癫痫。GAD65,通过γ-aminobutyric acid-ergic神经元,GlyR在视网膜上互动。光学相干断层扫描(OCT)曾被用于各种神经系统疾病建立基线特征和监测疾病进程。这提出了一个非侵入性评估的机会的生物标志物可能协助这些罕见但衰弱疾病的治疗。
设计/方法10月措施RNFL的行业研究GAD65和GlyR神经患者自身免疫,与148年相比健康控制的眼睛。患者的基线特征也从病历回顾性分析。
结果的14个病人包括在这项研究中,12名患者是女性,平均年龄为52.6±16.8(22 - 79)年10月。十GAD65自身免疫和4 GlyR自身免疫。广泛性焦虑症或GlyR患者自身免疫显示低RNFL厚度在多个领域与健康对照组相比。这个结果在anti-GAD65抗体组最为明显。11个病人SPSD,一个病人癫痫,和两个非特异性症状。
结论这项研究提供了洞察基线RNFL厚度在一群GAD65 GlyR自身免疫,两个条件,可能会产生不同的症状。当样本容量有限,RNFL GAD65薄被,GlyR自身免疫组,在anti-GAD65组最为明显。这提供了一个基线特征,表明未来的研究应该进行确定10月的效用作为这些疾病的生物标志物。
脚注
披露:Hoshina博士没有披露。黄西的机构收到生原体研究支持Idec。加利博士没有披露。Greenlee博士已经收到个人薪酬在500 - 4999美元的范围作为一个编辑,副主编,Medlink或编辑顾问委员会成员。Greenlee博士已经收到相关出版物的出版版税卫生保健。Greenlee博士已经收到相关出版物的出版版税卫生保健。立即家人克莱恩女士已收到个人赔偿作为安进公司的员工。立即家人克莱恩女士已收到个人薪酬在500 - 4999美元的范围在安进的演讲人。巴斯博士苏丹已收到个人薪酬在500 - 4999美元的范围为TG疗法作为顾问。巴斯博士的机构苏丹已经收到了来自美国国立卫生研究院的研究支持。 The institution of Dr. Paz Soldan has received research support from National Multiple Sclerosis Society. The institution of Dr. Paz Soldan has received research support from Western Institute for Biomedical Research. The institution of Dr. Paz Soldan has received research support from Biogen. The institution of Dr. Paz Soldan has received research support from Novartis. The institution of Dr. Paz Soldan has received research support from Clene Nanomedicine. Dr. Clardy has received personal compensation for serving as an employee of Veterans Health Administration (VHA). Dr. Clardy has received personal compensation for serving as an employee of University of Utah Health. Dr. Clardy has received personal compensation in the range of $0-$499 for serving as a Consultant for Clarion. Dr. Clardy has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ExpertConnect. The institution of Dr. Clardy has received personal compensation in the range of $0-$499 for serving as a Consultant for VielaBio. The institution of Dr. Clardy has received personal compensation in the range of $0-$499 for serving as a Consultant for Genentech. The institution of Dr. Clardy has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. The institution of Dr. Clardy has received personal compensation in the range of $0-$499 for serving as a Consultant for GuidePoint. Dr. Clardy has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology/AAN Publications. The institution of Dr. Clardy has received research support from Alexion Pharma. The institution of Dr. Clardy has received research support from Sumaira Foundation for NMO. The institution of Dr. Clardy has received research support from Immune Deficiency Foundation. The institution of Dr. Clardy has received research support from Western Institute for Veteran Research. The institution of Dr. Clardy has received research support from NIH/NINDS. Dr. Clardy has received personal compensation in the range of $500-$4,999 for serving as a AAN Summer Meeting CoDirector Travel and Lodging with AAN. Dr. Clardy has received personal compensation in the range of $500-$4,999 for serving as a Grand Rounds Travel and Lodging with U of Iowa. Dr. Clardy has received personal compensation in the range of $500-$4,999 for serving as a Speaker Honoraria for Grand Rounds with Barrow Neurological Institute. Dr. Fjeldstad has nothing to disclose. The institution of Dr. Rose has received research support from National Multiple Sclerosis Society. The institution of Dr. Rose has received research support from Guthy Jackson Charitable Foundation. The institution of Dr. Rose has received research support from NIH. The institution of Dr. Rose has received research support from Friend's of MS. The institution of Dr. Rose has received research support from Biogen. Dr. Rose has received intellectual property interests from a discovery or technology relating to health care. Dr. Kadish has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. The institution of Dr. Kadish has received research support from Alexion Pharmaceuticals.
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