调节补充与Fc受体γ受体3积极的自然杀伤细胞(NK)和自然杀伤t细胞(NKT)视Neuromyelitis谱系障碍
文摘
客观的澄清如果NK和NKT细胞被激活在NMOSD通过补充。
背景抑制终端补NMOSD使用eculizumab已被证明是有用的在预防复发,但药物如何工作还不清楚。同样,在Fc 3γ受体基因变异与结果NMOSD但这些FcGR3A受体表达的免疫细胞是未知的。我们比较FcGR3A表情免疫细胞调节NK细胞补充活动和NKT细胞NMOSD疾病控制和健康的人。
设计/方法外周血细胞(PBMC)样本与AQP4-IgG 45 NMOSD患者,18疾病控制和19分析了正常对照组FcGR3A体外受体表达和补充。
结果在基线,在NMOSD NKT细胞的数量增加(p < 0.001),但FcGR3A积极的比例低于健康和疾病控制(p = 0.0012)。NK细胞计数正常基线也不过FcGR3A积极的比例也相对较低(p < 0.001)。NK细胞和NKT细胞从NMOSD C5补体受体表达健康和疾病控制相比要高得多(p < 0.001)。我们也评估激活标记CD69、CD83也更高的NK和NKT细胞NMOSD病人。
结论我们的研究结果支持模型的免疫发病机理模型中补体激活NK / NKT细胞移植FcGR3A表达式,结合抗体/抗原复合物。NMOSD的上下文中,这些complement-sensitive细胞可能是负责升级自身免疫活动。
脚注
披露:他没有透露博士。莱特女士没有披露。罗坍博士没有披露。保罗博士的机构已收到个人薪酬在500 - 4999美元的范围作为顾问三菱田边PC(调性)。保罗博士的机构已收到个人薪酬在500 - 4999美元的范围为奥尔胡斯大学担任顾问。保罗医生已收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会Alexion。保罗医生已收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会罗氏。保罗医生已收到个人补偿的范围0 - 499美元为科学顾问或服务为赛诺菲Genzyme数据安全监测委员会。保罗医生已收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会的联合制药公司。保罗医生已收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会CELGENE公司。 Dr. Paul has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer. Dr. Paul has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Paul has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for ACRELION. Dr. Paul has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Viela Bio. Dr. Paul has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Alexion. Dr. Paul has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Paul has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Pfizter. Dr. Paul has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck Serono. The institution of Dr. Paul has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer. Dr. Levy has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi Pharma. Dr. Levy has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB Pharma. Dr. Levy has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Levy has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. Dr. Levy has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Horizon. Dr. Levy has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Levy has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Levy has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Various law firms. The institution of Dr. Levy has received research support from National Institutes Health.
- ©2022美国神经病学学会的首页
信:快速的网络通信
你可能也会感兴趣
相关文章
-
没有找到相关文章。