2022年12月06日
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MRI-Visible血管周的空间和事件发生痴呆的风险
弗雷明汉心脏研究
第一次出版2022年9月29日,
DOI: https://doi.org/10.1212/WNL.0000000000201293
何塞·拉斐尔·罗梅罗
从神经学部门(J.R.R.首页,H.J.A.), Boston University School of Medicine, MA; Department of Biostatistics (A.P. S.D.), Boston University School of Public Health, MA; Department of Neurology (C.S.D.), University of California at Davis, CA; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio, TX; and NHLBI's Framingham Heart Study (J.R.R., A.P., H.J.A., S.D., S.S.), MA.
医学博士
ibsen Pinheiro Adlin
从神经学部门(J.R.R.首页,H.J.A.), Boston University School of Medicine, MA; Department of Biostatistics (A.P. S.D.), Boston University School of Public Health, MA; Department of Neurology (C.S.D.), University of California at Davis, CA; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio, TX; and NHLBI's Framingham Heart Study (J.R.R., A.P., H.J.A., S.D., S.S.), MA.
马
雨果·j·Aparicio
从神经学部门(J.R.R.首页,H.J.A.), Boston University School of Medicine, MA; Department of Biostatistics (A.P. S.D.), Boston University School of Public Health, MA; Department of Neurology (C.S.D.), University of California at Davis, CA; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio, TX; and NHLBI's Framingham Heart Study (J.R.R., A.P., H.J.A., S.D., S.S.), MA.
医学博士
Charles s . DeCarli
从神经学部门(J.R.R.首页,H.J.A.), Boston University School of Medicine, MA; Department of Biostatistics (A.P. S.D.), Boston University School of Public Health, MA; Department of Neurology (C.S.D.), University of California at Davis, CA; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio, TX; and NHLBI's Framingham Heart Study (J.R.R., A.P., H.J.A., S.D., S.S.), MA.
医学博士
Serkalem Demissie
从神经学部门(J.R.R.首页,H.J.A.), Boston University School of Medicine, MA; Department of Biostatistics (A.P. S.D.), Boston University School of Public Health, MA; Department of Neurology (C.S.D.), University of California at Davis, CA; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio, TX; and NHLBI's Framingham Heart Study (J.R.R., A.P., H.J.A., S.D., S.S.), MA.
博士学位
Sudha Seshadri
从神经学部门(J.R.R.首页,H.J.A.), Boston University School of Medicine, MA; Department of Biostatistics (A.P. S.D.), Boston University School of Public Health, MA; Department of Neurology (C.S.D.), University of California at Davis, CA; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio, TX; and NHLBI's Framingham Heart Study (J.R.R., A.P., H.J.A., S.D., S.S.), MA.
医学博士

文章数据和数据
数据
图2
例pv类别的大脑地形FHS的参与者
行椎体上部semiovale: (A)年级我(1 - 10 pv数),(B)二级(11日至20日pv数),(C)三级(意向pv数)和(D)年级第四(> 40 pv数)。底下一行基底神经节区:我(E)年级(1 - 10 pv数),(F)二级(11日至20日pv数),(G)三级(意向pv数)和(H)等级IV (> 40 pv数)。pv =血管周的空间,FHS =弗雷明汉心脏研究。
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图3
调整全因痴呆pv类别和地形的生存曲线
pv =血管周的空间。*调整了年龄、性别、和磁共振成像和之间的时间间隔检查周期,队列,教育、吸烟、糖尿病、高血压和心血管疾病流行。