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Dr. Royall's comment on our article draws attention to their study,1,2 which found that among ≥100 serum proteins, the interaction of c-reactive protein (CRP) and apolipoprotein ε4 (APOE4) was associated with dementia after Bonferroni correction. We believe that the study confirms our results.1 To date, at least 4 different cohorts have found that increasing levels of blood CRP affected Alzheimer disease (AD) dementia risk in APOE4 carriers,1-4 suggesting that peripheral CRP is a pathologic mediator in APOE4 risk for AD.
Footnotes
Author disclosures are available upon request (journal{at}neurology.org).
- Received September 19, 2022.
- Accepted in final form September 19, 2022.
- © 2022 American Academy of Neurology
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