This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Tao et al.1 have described an interaction between elevated plasma C-reactive protein (CRP) levels and APOE ε4 burden in data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). They concluded that “CRP released during peripheral inflammation could be a mediator in APOE ε4–related AD neurodegeneration and serve as a drug target for AD.”1 We demonstrated CRP's mediation in data from the Texas Alzheimer's Research and Care Consortium (TARCC), a larger, ethnically diverse, and similarly well-characterized cohort, in 2017.2 The TARCC measures blood-based protein biomarkers in serum by the same methodology and vendor as the ADNI. In our paper, we tested N = 120 serum proteins, and only CRP had an unequivocal mediation effect on the association of APOE with prospectively measured and highly adjusted dementia severity.
Footnotes
Author disclosures are available upon request (journal{at}neurology.org).
- Received September 19, 2022.
- Accepted in final form September 19, 2022.
- © 2022 American Academy of Neurology
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Hastening the Diagnosis of Amyotrophic Lateral Sclerosis
Dr. Brian Callaghan and Dr. Kellen Quigg