2022年2月1日
;98 (5)
科学杂志
双边丘脑病变与Atezolizumab-Induced脑炎有关
后续报告验尸结果
Haruo缝合,Tomoya今敏,Yusuke Seino,Norito Yagihashi,Chieko铃木,隆中村,Hisashi田中,Yui坂本,Koichi若林史江,雅彦五
第一次出版2021年11月19日,
DOI: https://doi.org/10.1212/WNL.0000000000013091
Haruo缝合
从神经学部门(H.N.首页,T.K.c。,T.N.,M.T.) and Neuropathology (K.W.), Institute of Brain Science, and Departments of Respiratory Medicine (H.T.) and Neuropsychiatry (Y. Sakamoto), Hirosaki University Graduate School of Medicine; Department of Neurology (H.N., T.N.), Hirosaki University Hospital; and Department of Neurology (Y. Seino) and Division of Pathology and Clinical Laboratory (N.Y.), Hirosaki National Hospital, Hirosaki City, Japan.
Tomoya今敏
从神经学部门(H.N.首页,T.K.c。,T.N.,M.T.) and Neuropathology (K.W.), Institute of Brain Science, and Departments of Respiratory Medicine (H.T.) and Neuropsychiatry (Y. Sakamoto), Hirosaki University Graduate School of Medicine; Department of Neurology (H.N., T.N.), Hirosaki University Hospital; and Department of Neurology (Y. Seino) and Division of Pathology and Clinical Laboratory (N.Y.), Hirosaki National Hospital, Hirosaki City, Japan.
Yusuke Seino
从神经学部门(H.N.首页,T.K.c。,T.N.,M.T.) and Neuropathology (K.W.), Institute of Brain Science, and Departments of Respiratory Medicine (H.T.) and Neuropsychiatry (Y. Sakamoto), Hirosaki University Graduate School of Medicine; Department of Neurology (H.N., T.N.), Hirosaki University Hospital; and Department of Neurology (Y. Seino) and Division of Pathology and Clinical Laboratory (N.Y.), Hirosaki National Hospital, Hirosaki City, Japan.
Norito Yagihashi
从神经学部门(H.N.首页,T.K.c。,T.N.,M.T.) and Neuropathology (K.W.), Institute of Brain Science, and Departments of Respiratory Medicine (H.T.) and Neuropsychiatry (Y. Sakamoto), Hirosaki University Graduate School of Medicine; Department of Neurology (H.N., T.N.), Hirosaki University Hospital; and Department of Neurology (Y. Seino) and Division of Pathology and Clinical Laboratory (N.Y.), Hirosaki National Hospital, Hirosaki City, Japan.
Chieko铃木
从神经学部门(H.N.首页,T.K.c。,T.N.,M.T.) and Neuropathology (K.W.), Institute of Brain Science, and Departments of Respiratory Medicine (H.T.) and Neuropsychiatry (Y. Sakamoto), Hirosaki University Graduate School of Medicine; Department of Neurology (H.N., T.N.), Hirosaki University Hospital; and Department of Neurology (Y. Seino) and Division of Pathology and Clinical Laboratory (N.Y.), Hirosaki National Hospital, Hirosaki City, Japan.
隆中村
从神经学部门(H.N.首页,T.K.c。,T.N.,M.T.) and Neuropathology (K.W.), Institute of Brain Science, and Departments of Respiratory Medicine (H.T.) and Neuropsychiatry (Y. Sakamoto), Hirosaki University Graduate School of Medicine; Department of Neurology (H.N., T.N.), Hirosaki University Hospital; and Department of Neurology (Y. Seino) and Division of Pathology and Clinical Laboratory (N.Y.), Hirosaki National Hospital, Hirosaki City, Japan.
Hisashi田中
从神经学部门(H.N.首页,T.K.c。,T.N.,M.T.) and Neuropathology (K.W.), Institute of Brain Science, and Departments of Respiratory Medicine (H.T.) and Neuropsychiatry (Y. Sakamoto), Hirosaki University Graduate School of Medicine; Department of Neurology (H.N., T.N.), Hirosaki University Hospital; and Department of Neurology (Y. Seino) and Division of Pathology and Clinical Laboratory (N.Y.), Hirosaki National Hospital, Hirosaki City, Japan.
Yui坂本
从神经学部门(H.N.首页,T.K.c。,T.N.,M.T.) and Neuropathology (K.W.), Institute of Brain Science, and Departments of Respiratory Medicine (H.T.) and Neuropsychiatry (Y. Sakamoto), Hirosaki University Graduate School of Medicine; Department of Neurology (H.N., T.N.), Hirosaki University Hospital; and Department of Neurology (Y. Seino) and Division of Pathology and Clinical Laboratory (N.Y.), Hirosaki National Hospital, Hirosaki City, Japan.
Koichi若林史江
从神经学部门(H.N.首页,T.K.c。,T.N.,M.T.) and Neuropathology (K.W.), Institute of Brain Science, and Departments of Respiratory Medicine (H.T.) and Neuropsychiatry (Y. Sakamoto), Hirosaki University Graduate School of Medicine; Department of Neurology (H.N., T.N.), Hirosaki University Hospital; and Department of Neurology (Y. Seino) and Division of Pathology and Clinical Laboratory (N.Y.), Hirosaki National Hospital, Hirosaki City, Japan.
雅彦五
从神经学部门(H.N.首页,T.K.c。,T.N.,M.T.) and Neuropathology (K.W.), Institute of Brain Science, and Departments of Respiratory Medicine (H.T.) and Neuropsychiatry (Y. Sakamoto), Hirosaki University Graduate School of Medicine; Department of Neurology (H.N., T.N.), Hirosaki University Hospital; and Department of Neurology (Y. Seino) and Division of Pathology and Clinical Laboratory (N.Y.), Hirosaki National Hospital, Hirosaki City, Japan.
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一名72岁的妇女被临床诊断为atezolizumab-induced脑炎。1她的临床特征是先前描述1这里我们提出尸检结果。她对待atezolizumab,免疫抑制剂检查站(ICI),由于转移性非小细胞肺癌的诊断。她收到了她最后atezolizumab注入脑炎发病后3周,停止和癌症治疗。尽管两国丘脑病灶萎缩类固醇脉冲后,静脉注射免疫球蛋白,和长期口服类固醇,病人死于脑炎发病后吸入性肺炎7个月。尸检显示没有证据表明癌症的复发。大脑只组织学分析显示淋巴细胞浸润到丘脑,无感染或转移(图)。和B - t细胞浸润是伴随着神经损失和丘脑神经胶质过多症。t细胞浸润在协议与以前的工作描述ICI-induced脑炎,2表明机械的重叠与脑炎/脑病引起多种症状。这种情况也表明,B细胞的炎症过程。
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去首页Neurology.org/N为充分披露。资金信息和披露认为作者相关的,如果有的话,年底提供这篇文章。
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