文摘
摘要目的:本研究调查的影响COVID-19最近在大脑组织中恢复COVID-19通过自我孤立。
背景:微观结构差异的比较中曾发现了COVID-19患者控制,特别是在地区与嗅觉系统有关。嗅觉系统与尾状,壳核、丘脑、楔前叶、扣带地区。
设计/方法:这里我们报告扩散磁共振成像(3 T西门子核磁共振)发现40例(平均年龄:43.7,68%女性)后自我孤立的测试阳性COVID (x +)和14 COVID负(浸−)科目(平均年龄:43,64%女性)流感样症状。这是加拿大NeuroCOVID-19研究的一部分。
分数各向异性(FA)、平均扩散系数(MD)的各向异性(MO)模式,自由水比例(F),组织FA(脂肪)和组织MD(联合化疗)获得使用数据与b = 700年和1400年(DIPY自由液模型)。区域的灰质和白质的兴趣使用FreeSurfer划定。组之间的差异评估使用方差分析(方差分析),克鲁斯卡尔-沃利斯检验和Mann-Whitney测试,纠正错误发现率为0.05。效果(科恩的d)也计算(d > 0.45认为大效果)。
结果:浸+组中,所有三个测试结果显示脑岛FA和脂肪减少,并增加parstriangularis皮层的MD。增加了FA和脂肪楔片(以及减少MD)也被发现。在x + MD减少时间和supramarginal地区。莫在x +低岛叶和杏仁核区域。
结论:较低的患者,更高的MD FA和莫建议增加细胞外体液,而降低MD与降低FA和莫可能表明坏死碎片建立后炎症。楔片和脑岛参与视觉和味觉处理,分别。这项研究强调了需要研究COVID-19神经的影响。
披露:出纳员没有披露先生。乍得先生没有披露。Roudaia博士没有披露。博士Hashemi没有披露。Grosbein太太没有披露。基利波山Asaf没有披露。Goubran博士没有披露。程博士没有披露。黑色博士已经收到个人薪酬在5000 - 9999美元的范围为罗氏公司担任顾问。黑色博士已经收到个人薪酬在5000 - 9999美元的范围在生原体的演讲人。 The institution of Dr. Black has received research support from Hoffmann-La Roche. The institution of Dr. Black has received research support from Biogen. The institution of Dr. Black has received research support from GE Healthcare. The institution of Dr. Black has received research support from Lilly Avid. The institution of Dr. Black has received research support from Genentech. Chinthaka Heyn has received stock or an ownership interest from 11317423 CANADA LTD.. Chinthaka Heyn has received intellectual property interests from a discovery or technology relating to health care. Dr. Gao has nothing to disclose. Dr. Masellis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Arkuda Therapeutics. Dr. Masellis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ionis. Dr. Masellis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alector. Dr. Masellis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Wave Life Sciences. The institution of Dr. Masellis has received research support from Canadian Institutes of Health Research. The institution of Dr. Masellis has received research support from Ontario Brain Institute. The institution of Dr. Masellis has received research support from Weston Brain Institute. The institution of Dr. Masellis has received research support from Washington University. The institution of Dr. Masellis has received research support from Alector. Dr. Masellis has received publishing royalties from a publication relating to health care. Dr. Rabin has nothing to disclose. Mr. Ji has nothing to disclose. The institution of Mr. Jegatheesan has received research support from Siemens Healthineers. Benjamin Lam has nothing to disclose. Bradley MacIntosh has nothing to disclose. Dr. Graham has received intellectual property interests from a discovery or technology relating to health care. Dr. Chen has nothing to disclose.
