文摘
摘要目的:探索逐步功能连通性(证监会)重组影响患者额颞叶大叶性变性(FTLD)变异。
背景:尽管FTLD临床表现分享额叶和颞叶的伤害,有一个明显的分歧在大脑网络的脆弱性,导致异构症状伴随行为变异的额颞叶痴呆(bvFTD)和迟滞型(nfvPPA)和语义变体原发性进行性失语(svPPA)。证监会分析是一个graph-theory-based神经影像学方法,检测整个大脑功能耦合的选择感兴趣的区域,增加link-step距离。
设计/方法:患者bvFTD (n = 26), nfvPPA (n = 11)或svPPA (n = 14)进行了临床评估和3 t MRI扫描。对于每个子群,皮质厚度进行评估,以确定萎缩的峰值(视为疾病中心),与37岁相比,sex-matched健康对照组。这些区域被用作随后证监会种子区域分析。
结果:选择种子区域的右眶额皮层bvFTD, nfvPPA左辅助运动区,左颞极svPPA。与控制相比,病人三个组表现为广泛的地区,香港证监会降低直接与各自的种子/中间连接的地区。bvFTD nfvPPA病人也显示增加香港证监会在大脑区域靠近各自的种子区域和同源侧皮质link-step。进一步link-steps,证监会增加也观察到后小脑bvFTD nfvPPA病人,和优越的额叶皮层svPPA病人。
结论:我们的研究结果表明增加短程FTLD的直接连接在疾病中心之一,可能在与神经退化补偿,普遍功能重组,每个不同link-steps表型特征。这是第一个研究探索证监会FTLD的开放承诺的角度理解这些演讲和模型的physiopathological基础疾病的演变。
披露:博士利沃诺主席没有披露。Falbo博士没有披露。西尔维亚Basaia没有披露。卡米拉Cividini没有披露。尼洛莉娃没有披露。Elisa Canu的机构已经收到了来自意大利卫生部的研究支持。Veronica Castelnovo没有披露。朱塞佩•马格纳尼没有披露。卡索博士没有披露。Paola Caroppo没有披露。 Sara Prioni has nothing to disclose. Dr. Rossi has nothing to disclose. Lucio Tremolizzo has nothing to disclose. Dr. Appollonio has nothing to disclose. Dr. Silani has nothing to disclose. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA). Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
