2022年1月4日,
;98 (1)
金博宝手机版官网首页
开放获取
预测事件发生轻度认知障碍及其在不同社区的人口
第一次出版2021年12月1日,
DOI: https://doi.org/10.1212/WNL.0000000000013017
Milou j . Angevaare
从神经学和托布研究所研究阿尔茨海默病和衰老的大首页脑(M.J.A.,J.M.J.V.,第2,L.Z.,C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
飞机M.J. Vonk
从神经学和托布研究所研究阿尔茨海默病和衰老的大首页脑(M.J.A.,J.M.J.V.,第2,L.Z.,C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
Laiss Bertola
从神经学和托布研究所研究阿尔茨海默病和衰老的大首页脑(M.J.A.,J.M.J.V.,第2,L.Z.,C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
劳拉Zahodne
从神经学和托布研究所研究阿尔茨海默病和衰老的大首页脑(M.J.A.,J.M.J.V.,第2,L.Z.,C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
凯特琳伟明沃森
从神经学和托布研究所研究阿尔茨海默病和衰老的大首页脑(M.J.A.,J.M.J.V.,第2,L.Z.,C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
阿米莉亚伯麦
从神经学和托布研究所研究阿尔茨海默病和衰老的大首页脑(M.J.A.,J.M.J.V.,第2,L.Z.,C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
妮可Schupf
从神经学和托布研究所研究阿尔茨海默病和衰老的大首页脑(M.J.A.,J.M.J.V.,第2,L.Z.,C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
理查德马斯
从神经学和托布研究所研究阿尔茨海默病和衰老的大首页脑(M.J.A.,J.M.J.V.,第2,L.Z.,C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
Mirjam i Geerlings
从神经学和托布研究所研究阿尔茨海默病和衰老的大首页脑(M.J.A.,J.M.J.V.,第2,L.Z.,C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
詹妮弗·j .男子气概的
从神经学和托布研究所研究阿尔茨海默病和衰老的大首页脑(M.J.A.,J.M.J.V.,第2,L.Z.,C.W.-M.W., A.B., N.S., R.M., J.J.M.), College of Physicians and Surgeons, Columbia University, New York, NY; Julius Center for Health Sciences and Primary Care (M.J.A., J.M.J.V., M.I.G.), University Medical Center Utrecht; Amsterdam UMC (M.J.A.), Vrije Universiteit Amsterdam, Department of Medicine for Older People, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, the Netherlands; and National Institute of Science and Technology in Molecular Medicine (L.B.), Federal University of Minas Gerais, Belo Horizonte, Brazil.
做出评论
看到评论
文摘
背景和目标调查社会人口和医疗事件的预测因子轻度认知障碍(MCI)和随后的MCI在随访过程中,包括持续MCI诊断、分类认知正常,发展为痴呆。
方法在以社区为基础的群体,MCI是用发表算法的诊断。痴呆的诊断是根据临床共识。Cox回归估计风险事件MCI的比率与几个预测。修改的泊松回归估计的相对风险预测诊断状态在随访后发病率。
结果在2903认知正常受试者基线,752发达MCI平均6.3(标准差4.5)年(每1000人年发病率56)。的存在APOEε4事件的风险增加MCI和更高的医疗负担,而多年的教育,更多的休闲活动,高收入减少这种风险。入射MCI的情况下,后平均2.4年的随访中,有12.9%发展为痴呆,功能下降9.6%,没有满足MCI的算法标准但未达到痴呆的临床标准,29.6%继续满足MCI标准,47.9%不再满足MCI标准。多畴的MCI的存在APOEε4,抑郁症状,抗抑郁药物使用增加发展为痴呆的风险。
讨论以社区为基础的研究显示,几乎一半的人与事件MCI诊断分为认知正常跟踪。事件的预测MCI明显不同于随后的MCI的课程;这些发现可以改善认知和预期功能,MCI。
术语表
- DSM-III=
- 精神疾病诊断与统计手册,第3版;
- MCI=
- 轻度认知障碍;
- WHICAP=
- 华盛顿哥伦比亚老化Heights-Inwood项目
脚注
去首页Neurology.org/N为充分披露。资金信息和披露认为作者相关的,如果有的话,年底提供这篇文章。
这篇文章加工费由国立卫生研究院资助。
CME过程:NPub.org/cmelist
- 收到了2020年11月19日。
- 接受的最终形式2021年9月29日。
- 版权©2021年作者(年代)。发表的Wolters Kluwer健康,公司代表美国神经病学学会。首页
这是一个开放的分布式根据文章Creative Commons Attribution-NonCommercial-NoDerivatives许可证4.0 (CC BY-NC-ND),它允许下载和共享工作提供适当的引用。不能改变的工作以任何方式或使用未经许可的商业杂志。