文章数据和数据
数据
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图1 连接家庭中的相关基因全身性癫痫(专家组)成像模式
(一)个人全球连接的值和兄弟姐妹兼顾患者策划对于他们的家庭成员(频带内的数据列)。兼顾患者的数据没有相应的兄弟姐妹没有显示。专家组综合症的病人在每个家庭在x轴上表示。儿童失神癫痫和少年失神癫痫是指没有癫痫(AE)。(B)彩色编码遗传可能性的估计(组内相关(ICC)值)/地区基于Desikan-Kiliany地图集26小到大组级别专家组和控制(科恩患者之间的差别d> 0.2)。只有ICC地图以积极和显著相关性平均效应大小显示(p< 0.05)。彩色编码显示ICC的强度值在这些地区连接的差异。ICC来自随机效应估计组件每个地区的混合模型,考虑到集团和年龄的影响。大型国际刑事法庭表示patient-sibling相关成像模式对一个家庭(n = 14),因此指标的遗传。皮质区域显示在左列和皮质下区域分别显示在右列的阴谋。gtc =广义tonic-clonic发作;期刊=青少年肌阵挛癫痫。
(一)个人全球力量值患者专家组和兄弟姐妹的关于他们的家庭成员(频带内的数据列)。兼顾患者的数据没有相应的兄弟姐妹没有显示。专家组综合症的病人在每个家庭在x轴上表示。儿童失神癫痫和少年失神癫痫是指没有癫痫(AE)。用于可视化、电力数据log10-transformed。(B)彩色编码遗传可能性的估计(组内相关(ICC)值)/地区基于Desikan-Kiliany地图集26小到大组级别专家组和控制(科恩患者之间的差别d> 0.2)。只有ICC地图以积极和显著相关性平均效应大小显示(p< 0.05)。彩色编码显示在这些地区刑事法庭的强度值对权力差异。ICC来自随机效应估计组件每个地区的混合模型,考虑到集团和年龄的影响。大型国际刑事法庭表示patient-sibling相关成像模式对一个家庭(n = 14),因此指标的遗传。皮质区域显示在左列和皮质下区域分别显示在右列的阴谋。gtc =广义tonic-clonic发作;期刊=青少年肌阵挛癫痫。
(一)小提琴情节显示单个数据点,的密度数据,组织方式,和标准错误意味着全球虚部的一致性在每个频带(控制,n = 45;兄弟姐妹,n = 18;遗传全身性癫痫患者(专家组),n = 25)。星号*表示统计学意义p< 0.05和* *p< 0.001 permutation-based组比较。(B)情节突出顶点与患者连接值明显高于专家组(n = 25)比在控制(n = 45)和(C)更高的连接值(n = 25)兼顾患者比兄弟姐妹(n = 18)。颜色显示log10规模p截止1.3(对应p< 0.05,familywise错误纠正)。在所有分析,年龄是作为协变量的不感兴趣。
(一)小提琴情节显示单个数据点,的密度数据,意味着,全球力量的手段和标准错误每个频带(控制,n = 45;兄弟姐妹,n = 18;遗传全身性癫痫患者(专家组),n = 25)。星号*表示统计学意义p< 0.05和* *p< 0.001 permutation-based组比较。用于可视化、电力数据log10-transformed。(B)情节强调大脑皮层和皮层下顶点更高功率值(n = 25)兼顾患者比控制(n = 45)。(C)情节显示与更高的功率值顶点(n = 25)兼顾患者比兄弟姐妹(n = 18)。颜色显示−log10规模p截止1.3(对应p< 0.05,familywise错误纠正)。在所有分析,年龄是作为协变量的不感兴趣。
顶点情节凸显皮质高的顶点(A)连接和(B)功率值遗传全身性癫痫患者(专家组)和广义棘波放电(GSWD) (n = 9)患者比没有GSWD在脑录音(n = 16)。这些影响在场后排除试验包含GSWD±10秒的数据和纠正年龄的影响。(C)情节显示显著降低连接兼顾患者服用2个或更多的抗癫痫药物(n = 6)患者比服用少于2药物(n = 19)在研究日期。年龄和有无GSWD作为协变量不感兴趣。颜色刻度指示log10p截止1.3(对应p< 0.05,familywise错误纠正)。
![Connectivity Within Families Related to Genetic Generalized Epilepsy (GGE) Imaging Patterns (A) Individual global connectivity values of patients with GGE and siblings are plotted with regard to their family membership (columns of data within frequency bands). Data of patients with GGE without a corresponding sibling are not shown. GGE syndromes of patients in each family are indicated on the x-axis. Childhood absence epilepsy and juvenile absence epilepsy are referred to absence epilepsies (AE). (B) Color-coded heritability estimates (intraclass correlation [ICC] values) per region based on the Desikan-Kiliany atlas26 with small to large group-level differences between patients with GGE and controls (Cohen d > 0.2). Only ICC maps with a positive and significant correlation with averaged effect sizes are shown (p < 0.05). The color coding indicates the strength of ICC values in those regions for connectivity differences. ICC estimates were derived from random effect components of mixed models for each region, taking group and age effects into account. A large ICC indicates correlated imaging patterns for patient–sibling pairs in a family (n = 14) and thus heritability of the metrics. Cortical regions are displayed in the left column and subcortical regions are shown separately in the right column of the plot. GTCS = generalized tonic-clonic seizures; JME = juvenile myoclonic epilepsy.](http://www.ez-admanager.com/content/neurology/97/2/e166/F1.large.jpg?width=800&height=600&carousel=1){kind=link}
![Power Within Families Related to Genetic Generalized Epilepsy (GGE) Imaging Patterns (A) Individual global power values of patients with GGE and siblings are plotted with regard to their family membership (columns of data within frequency bands). Data of patients with GGE without a corresponding sibling are not shown. GGE syndromes of patients in each family are indicated on the x-axis. Childhood absence epilepsy and juvenile absence epilepsy are referred to absence epilepsies (AE). For visualization purposes, power data were log10-transformed. (B) Color-coded heritability estimates (intraclass correlation [ICC] values) per region based on the Desikan-Kiliany atlas26 with small to large group-level differences between patients with GGE and controls (Cohen d > 0.2). Only ICC maps with a positive and significant correlation with averaged effect sizes are shown (p < 0.05). The color coding indicates the strength of ICC values in those regions for power differences. ICC estimates were derived from random effect components of mixed models for each region, taking group and age effects into account. A large ICC indicates correlated imaging patterns for patient–sibling pairs in a family (n = 14) and thus heritability of the metrics. Cortical regions are displayed in the left column and subcortical regions are shown separately in the right column of the plot. GTCS = generalized tonic-clonic seizures; JME = juvenile myoclonic epilepsy.](http://www.ez-admanager.com/content/neurology/97/2/e166/F2.large.jpg?width=800&height=600&carousel=1){kind=link}
![Group-Level Connectivity Differences (A) Violin plots show individual data points, the density of the data, group means, and standard errors of the means for the global imaginary part of coherency in each frequency band (controls, n = 45; siblings, n = 18; patients with genetic generalized epilepsy [GGE], n = 25). Asterisks denote statistical significance at *p < 0.05 and **p < 0.001 for permutation-based group comparisons. (B) The plot highlights vertices with significantly higher connectivity values in patients with GGE (n = 25) than in controls (n = 45) and (C) higher connectivity values in patients with GGE (n = 25) than in siblings (n = 18). The color scale indicates –log10 p with a cutoff of 1.3 (corresponding to p < 0.05, familywise error corrected). In all analyses, age was included as covariate of no interest.](http://www.ez-admanager.com/content/neurology/97/2/e166/F3.large.jpg?width=800&height=600&carousel=1){kind=link}
![Group-Level Power Differences (A) Violin plots show individual data points, the density of the data, group means, and standard errors of the means for global power in each frequency band (controls, n = 45; siblings, n = 18; patients with genetic generalized epilepsy [GGE], n = 25). Asterisks denote statistical significance at *p < 0.05 and **p < 0.001 for permutation-based group comparisons. For visualization purposes, power data were log10-transformed. (B) The plot highlights cortical and subcortical vertices with significantly higher power values in patients with GGE (n = 25) than in controls (n = 45). (C) The plot shows vertices with significantly higher power values in patients with GGE (n = 25) than in siblings (n = 18). The color scale indicates −log10 p with a cutoff of 1.3 (corresponding to p < 0.05, familywise error corrected). In all analyses, age was included as covariate of no interest.](http://www.ez-admanager.com/content/neurology/97/2/e166/F4.large.jpg?width=800&height=600&carousel=1){kind=link}
