%PDF-1.4
%
145 0 obj
<>
endobj
144 0 obj
<>stream
Acrobat Distiller 7.0 (Windows)
23th June 2020
2023-08-17T12:02:03-07:00
0-00-00T20:20:00Z
Arbortext Advanced Print Publisher 9.1.510/W Unicode
2023-08-17T12:02:03-07:00
application/pdf
Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline
uuid:8336c674-fdb6-4722-af35-9fba3040159b
uuid:fb1f3dec-1dd1-11b2-0a00-b800f84efbff
23th June 2020
endstream
endobj
141 0 obj
<>
endobj
7 0 obj
<>
endobj
2 0 obj
<>
endobj
30 0 obj
<>
endobj
86 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
87 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
147 0 obj
<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/Type/Page>>
endobj
152 0 obj
[159 0 R 160 0 R 161 0 R 162 0 R 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R 168 0 R]
endobj
153 0 obj
<>stream
q
192 0 0 51 200.5 659 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
12 0 0 12 200.00812 570.99988 Tm
(DOI 10.1212/WNL.0000000000009277)Tj
-2.97149 1 Td
(2020;95;e320-e331 Published Online before print March 25, 2020)Tj
/T1_1 1 Tf
-4.47201 0 Td
(Neurology\240)Tj
/T1_0 1 Tf
4.97199 1.00001 Td
(Joanne Ryan, Elsdon Storey, Anne M. Murray, et al. )Tj
/T1_2 1 Tf
8.8875 1 Td
(decline)Tj
-16.91546 1 Td
(Randomized placebo-controlled trial of the effects of aspirin on dementi\
a and cognitive)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 172.00607 544 Tm
(This information is current as of March 25, 2020)Tj
ET
72 253 449 283 re
0 0 m
S
BT
/T1_2 1 Tf
10 0 0 10 82 506.99997 Tm
(Services)Tj
0 1 TD
(Updated Information &)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 410.1698 506.99997 Tm
( )Tj
0 0 1 rg
-17.91698 0 Td
(http://n.neurology.org/content/95/3/e320.full)Tj
0 g
T*
(including high resolution figures, can be found at:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 82 484 Tm
(References)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 450.15958 473.99997 Tm
( )Tj
0 0 1 rg
-21.91596 0 Td
(http://n.neurology.org/content/95/3/e320.full#ref-list-1)Tj
0 g
T*
(This article cites 35 articles, 6 of which you can access for free at: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 82 456 Tm
(Citations)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 469.59973 445.99997 Tm
( )Tj
0 0 1 rg
-23.85997 0 Td
(http://n.neurology.org/content/95/3/e320.full##otherarticles)Tj
0 g
T*
(This article has been cited by 3 HighWire-hosted articles: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 82 428 Tm
(Subspecialty Collections)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 510.4498 327.99969 Tm
( )Tj
0 0 1 rg
-27.94498 0 Td
(http://n.neurology.org/cgi/collection/mci_mild_cognitive_impairment)Tj
0 g
/T1_2 1 Tf
T*
(MCI \(mild cognitive impairment\))Tj
/T1_0 1 Tf
9.609 1.00001 Td
( )Tj
0 0 1 rg
-9.609 0 Td
(lled_consort_agreement)Tj
T*
(http://n.neurology.org/cgi/collection/clinical_trials_randomized_contro)Tj
0 g
/T1_2 1 Tf
T*
(Clinical trials Randomized controlled \(CONSORT agreement\))Tj
/T1_0 1 Tf
22.498 1.00001 Td
( )Tj
0 0 1 rg
-22.498 0 Td
(http://n.neurology.org/cgi/collection/alzheimers_disease)Tj
0 g
/T1_2 1 Tf
T*
(Alzheimer's disease)Tj
/T1_0 1 Tf
25.445 1 Td
( )Tj
0 0 1 rg
-25.445 0 Td
(http://n.neurology.org/cgi/collection/all_cbmrt_null_hypothesis)Tj
0 g
/T1_2 1 Tf
T*
(All CBMRT/Null Hypothesis)Tj
/T1_0 1 Tf
0 1.00001 TD
(following collection\(s\): )Tj
0 1 TD
(This article, along with others on similar topics, appears in the)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 82 299.99997 Tm
(\240 )Tj
/T1_2 1 Tf
T*
(Permissions & Licensing)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 488.76996 289.99994 Tm
( )Tj
0 0 1 rg
-25.777 0 Td
(http://www.neurology.org/about/about_the_journal#permissions)Tj
0 g
T*
(its entirety can be found online at:)Tj
0 1.00001 TD
(Information about reproducing this article in parts \(figures,tables\) o\
r in)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 82 261.99997 Tm
(\240 )Tj
/T1_2 1 Tf
0 1 TD
(Reprints)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 405.42996 261.99997 Tm
( )Tj
0 0 1 rg
-17.443 0 Td
(http://n.neurology.org/subscribers/advertise)Tj
0 g
T*
(Information about ordering reprints can be found online:)Tj
ET
72 173 449 46 re
0 0 m
S
BT
/T1_0 1 Tf
10 0 0 10 77 180.99994 Tm
(rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X.)Tj
T*
(1951, it is now a weekly with 48 issues per year. Copyright \251 2020 Am\
erican Academy of Neurology. All )Tj
4.47202 1.00001 Td
(\256 is the official journal of the American Academy of Neurology. Publi\
shed continuously since)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
ET
q
246.75 0 0 77.25 173.125 77.75 cm
-1 TL /Im1 Do
Q
endstream
endobj
157 0 obj
<>stream
y]Cz+z]zk+ y܉7 zۉ6+ k]z ʸykzCyzyz zPl + z y z y z zk k 6 z]C+ z]C6 7Oz ] ʁO 6ʩzO ]ʁ ]C yl ]ʁ C 6 ʹk k z 6 l k C ] ]]B + ۹ z 6 ʁz C k 6 z ] Bz ʻz ]y 6+ y z ] O z y y y y * z z ʾ B z + C z 6 yz ] z6z P6 z C z + By Bz Bz 7]z P zy6] ]y y CC y y B7 y z zy C zz ^ PB ! y y y BkyC+B C 7 B zz O+C C 7B zz ]] B^ O Czz ^CBCBCP B B C ] B z y 6 B y B6 z Cz y ] 6 B C zz 66 zl B C zy z C Czy BzBk C z y zy C ] + C zz CO z B6 7 C zz z y6 C+ BBz6 zy +P*z C ]CzC z z ] C* B k B ykBC6+BClyʈ6 l+k] zʉPC6Oʩy^BC6 CBPz y zBCB 6ClyʙzBC7+BCPz ] C7z C B zk6 7zۙ]+ O ^ z+ yʉC 7k y ]+ +^ۉP 6]ۂ ] z C k C z] 6lC +zB+] zy ]k+ ^ z O 7C 6kCBC]zyz yzyz]BC PCz zyzCBCk+ ʹ6 C] B zB zyz^BC+ BzyzPC 7 C y kC + z ] ]+ 6 ] k C C B zB + ] B B zC + +z ] ]* zz B z6 ]k+ C6 ! C zP kC ] + z k+ + z] kC P z C y ^ B 6 C z 7kʹ]+ 7 C z ] yP BPBzzO O z +]ʹl7 + ]l+ ] + lBCPC 6 C z ]+] + z z C y* +O z B ]z k kzC zP+ CkzkB Bk B ]C z7+C ] z] y ^ Bz z Py 6]6 k+ Pz+ ] B ] Bz+! ^ 6y z* y l B6 C ] z P ! ] ] B 7 7 C By!B] B6 z C ]]C k+]6 6 z] 6 ] ] C6 kO C ] Cy lB6 z6 C+ 7 ]6 y ] 6 z 6 O+ z ] C] B y+ z CP 6zy CC lO Cz ]* z P y 6C7 Bz7 ]]6 z P B 6+ O6 ^ y ] + k C ۷ B7 B z ^ z z C ] 7+ z ^ 7 ] + B 7 Cy ]^ z BC ]] C P z O 6 ] C y ] k O C 7C y 6 7 ! z C +kCBy ] O + z C k + O C OB y C B y B k y O z l k BC B ]Cz P C k zB B B l y z ^O ^ C +B k l C z+ + C yCB P C z ! lz B 6 B C ] By z + zBB C ! Py z z C B C] CB 6 B z k6 zB BB y B y B ] O z+ C y B6 B z y zz7 y BCC ] z ^ O P C+ 6+ B C Cz* kyzyzyzylCBCBC z C CCz ] Pz 7 z Ck C B z zB C B 7 + z y 6 k Cl ] C B 6C zC zB B B C k z + z +z B 7+ C 6 B z C z C CB C O 7 6z 6 ] C yC C z ]B y l zB C C C k y ] y k C B l+ C ] ] Cz 6 O y B BBP P y + 6B ] O C C P Bz +kz yz yzyz yzyzyzyz z B CB z O ^ z O C z C C6 Bz + yC CB y 6z z z C C ] 7 B* B yk z z B B B z y B k z P ] ] C C z 6 yB C B z C +z O z z + C B z y B C Cz lC B z C B O +] B Cy zC B C yB Cz yz z + + B 7C z zB C B y+ z z zy l C]6Cz zy yCCB z y By y 6 O k C P 6 OC+ B ] PB y] y zC B Cy y C z] C+ B6 ] ByC zz BC B y z B z BC * ] + C6 ] B y C] y BB C z y C z B ^ ]+O] 6 z C C z 6 B yC CC y y Cy B y + z +y B y + y C B Cz y C z C z ] z *z Cz yB B C y k Cz Bz ! O O k 6 y Cz z B B C z C O y C z C Cyz z B y z z C C B z C y z B z P k + z y ] C y P y B C B z + zz ] z 6 +] y z C B y C zC BCz z yyO B ]] y7 zB y C C C z+ z z k C ]*!+ B ] z zz + zC ] y B CC z B z CCy6 *ۙ6 z z z z C B B yk z 6y P C]z]C+C z z y y BB B z O z ]z ! ] P + P z C z C C C z +] zB 6C k z C y yC CB y ! C z y k k k+y + + B z ] z 6 C z C CBy O 6y + z C +ll+ ]C y ^ y k z B B C z P k z C CB* 6Cz + ۢC y6 z 6 ] B C C y z ] ! ] P ܸ 6 ] ] P6z B C B B z O ] 6z 6 + ۡ C z P 6 B B B y O * z+ + 6ʩ z]B z 6 6 C y zy kC 6P*+ ۡ z ] C y z yk zy + * ] z y zy B y !+ z y ʠ ʸ ]y C+ C 7 C z y y + + + ] ] B ] y ^ z+ C+C* C + z z ]ʣ y y6 z ]6] z C z y + B O6 + C C ]6 y y 77^y * B P C k y l B l 6 7 z+ z+ k6 l B 76 ] k * O B C z + 6 6 k+ B 6 z k6 + y k +B B 6 + O 6 z 6 O * l O z6 ]] ] y ] ] P 6+ + ۳] y Ckl+ kz C l] ]67 C 6 + ] 7 B O ^ yO z]7y ] C 666 6ʣ k O+6 B 6kzC+ O l P] ] C P ] ʉB ]۷ C+ k k 6 ]+ + +]6 O^k Oz zyzy]CB Cz y۹zBC 6CPz C6 67 BB ʨy]B+CBz y + +B CzlC+ 6Pz k ]] + By B + B y ] C ]k CyP ] + *]k+ P ^ ] z ] kB6 *!!zC y C ] Py + O Cy C P B z+ z C Clz + C B] +6 O z] z7+z+ zl zC 6k 7B ] 6 l] +6 z ܧy!CBPzyz yz CBCB+6 P 6P P C Cz76C^zyz z yz yzyOCBC6 k+ 6 CBC]yzyz z yzykCBC*+P ]6 k ] +O B܈6 O C +kyC +Oۥ]+ CyP Bہ k ʨyPB* 6BkyPC+7Bk C+lʕʘyBC+CB]y۹z]BC +By Py O]z 6 ] ^ہ6 BC + 6 ] CPyz yzyz yz kC 6 6lۨl+ O z6C] ++6 z] 6 C 6 7 lz6 C ] 6y B z 7 l C] ہ B ] ]]C ] ہ C ] B C ] 6z C! CB l 7 B z +C C z P z* B P z B B P B B ] z ! + ]Bk^ ہ Oz ] ]+ y+ B ]C O Ck y k ] 7 7] + ] 7 ] ] z P ]B z] 6 6 zB6 ] y6 ^ ہ] O] y C 6kʨzCB C 7B 6CBCBCB ʁ ] ] + ʁ ] +ʁC ]B z+ +]CB]C +kʁl76zʁۘ]6 +Pzʹy ]CBCkzy
endstream
endobj
158 0 obj
<>/Filter/FlateDecode/Height 309/Length 29240/Name/X/Subtype/Image/Type/XObject/Width 987>>stream
H?Hi)B@HsPp#R$cHۜZZ%VVSeK<PX Ā"!!r70d>:S=3y۷}7b @Ҿ B<M3?2{ %ȣٜZ* JkӥZ nw;