%PDF-1.4
%
121 0 obj
<>
endobj
122 0 obj
<>stream
Acrobat Distiller 7.0 (Windows)
26th February 2020
2023-11-05T16:15:13-08:00
0-00-00T00:00:20Z
Arbortext Advanced Print Publisher 9.1.510/W Unicode
2023-11-05T16:15:13-08:00
application/pdf
NEUROLOGY2020056978 480..480
uuid:aec1d6cf-8560-4225-907b-b9b9a366e771
uuid:59d9fc0e-1dd2-11b2-0a00-6a00d8b4faff
26th February 2020
endstream
endobj
117 0 obj
<>
endobj
119 0 obj
<>
endobj
2 0 obj
<>
endobj
80 0 obj
<>
endobj
79 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
85 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
96 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
101 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
174 0 obj
<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/Type/Page>>
endobj
183 0 obj
[190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R]
endobj
184 0 obj
<>stream
q
192 0 0 51 236.5 695 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
12 0 0 12 236.00812 606.99988 Tm
(DOI 10.1212/WNL.0000000000009107)Tj
-3.02749 1 Td
(2020;94;481-494 Published Online before print February 26, 2020)Tj
/T1_1 1 Tf
-4.47201 0 Td
(Neurology\240)Tj
/T1_0 1 Tf
4.61251 1.00001 Td
(Alberto J. Espay, Lorraine V. Kalia, Ziv Gan-Or, et al. )Tj
/T1_2 1 Tf
7.44249 1 Td
(reconstruction?)Tj
-14.3065 1 Td
(Disease modification and biomarker development in Parkinson disease: Rev\
ision or)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 201.00412 580 Tm
(This information is current as of February 26, 2020)Tj
ET
108 319 449 253 re
0 0 m
S
BT
/T1_2 1 Tf
10 0 0 10 118 542.99997 Tm
(Services)Tj
0 1 TD
(Updated Information &)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 446.7298 542.99997 Tm
( )Tj
0 0 1 rg
-17.97298 0 Td
(http://n.neurology.org/content/94/11/481.full)Tj
0 g
T*
(including high resolution figures, can be found at:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 520 Tm
(References)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 486.71957 509.99997 Tm
( )Tj
0 0 1 rg
-21.97196 0 Td
(http://n.neurology.org/content/94/11/481.full#ref-list-1)Tj
0 g
T*
(This article cites 59 articles, 10 of which you can access for free at: \
)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 492 Tm
(Citations)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 506.15973 481.99997 Tm
( )Tj
0 0 1 rg
-23.91597 0 Td
(http://n.neurology.org/content/94/11/481.full##otherarticles)Tj
0 g
T*
(This article has been cited by 7 HighWire-hosted articles: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 464 Tm
(Subspecialty Collections)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 550.88019 393.99979 Tm
( )Tj
0 0 1 rg
-28.38802 0 Td
(http://n.neurology.org/cgi/collection/parkinsons_disease_parkinsonism)Tj
0 g
/T1_2 1 Tf
T*
(Parkinson disease/Parkinsonism)Tj
/T1_0 1 Tf
21.72199 1.00001 Td
( )Tj
0 0 1 rg
-21.72199 0 Td
(http://n.neurology.org/cgi/collection/all_clinical_trials)Tj
0 g
/T1_2 1 Tf
T*
(All Clinical trials)Tj
/T1_0 1 Tf
23.77698 1 Td
( )Tj
0 0 1 rg
-23.77698 0 Td
(http://n.neurology.org/cgi/collection/all_clinical_neurology)Tj
0 g
/T1_2 1 Tf
0 1.00001 TD
(All Clinical Neurology)Tj
/T1_0 1 Tf
0 1 TD
(following collection\(s\): )Tj
T*
(This article, along with others on similar topics, appears in the)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 365.99997 Tm
(\240 )Tj
/T1_2 1 Tf
T*
(Permissions & Licensing)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 524.76996 355.99994 Tm
( )Tj
0 0 1 rg
-25.777 0 Td
(http://www.neurology.org/about/about_the_journal#permissions)Tj
0 g
T*
(its entirety can be found online at:)Tj
0 1.00001 TD
(Information about reproducing this article in parts \(figures,tables\) o\
r in)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 327.99997 Tm
(\240 )Tj
/T1_2 1 Tf
0 1 TD
(Reprints)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 441.42996 327.99997 Tm
( )Tj
0 0 1 rg
-17.443 0 Td
(http://n.neurology.org/subscribers/advertise)Tj
0 g
T*
(Information about ordering reprints can be found online:)Tj
ET
108 209 449 46 re
0 0 m
S
BT
/T1_0 1 Tf
10 0 0 10 113 216.99994 Tm
(rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X.)Tj
T*
(1951, it is now a weekly with 48 issues per year. Copyright \251 2020 Am\
erican Academy of Neurology. All )Tj
4.47202 1.00001 Td
(\256 is the official journal of the American Academy of Neurology. Publi\
shed continuously since)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
ET
q
246.75 0 0 77.25 209.125 113.75 cm
-1 TL /Im1 Do
Q
endstream
endobj
188 0 obj
<>stream
y]Cz+z]zk+ y܉7 zۉ6+ k]z ʸykzCyzyz zPl + z y z y z zk k 6 z]C+ z]C6 7Oz ] ʁO 6ʩzO ]ʁ ]C yl ]ʁ C 6 ʹk k z 6 l k C ] ]]B + ۹ z 6 ʁz C k 6 z ] Bz ʻz ]y 6+ y z ] O z y y y y * z z ʾ B z + C z 6 yz ] z6z P6 z C z + By Bz Bz 7]z P zy6] ]y y CC y y B7 y z zy C zz ^ PB ! y y y BkyC+B C 7 B zz O+C C 7B zz ]] B^ O Czz ^CBCBCP B B C ] B z y 6 B y B6 z Cz y ] 6 B C zz 66 zl B C zy z C Czy BzBk C z y zy C ] + C zz CO z B6 7 C zz z y6 C+ BBz6 zy +P*z C ]CzC z z ] C* B k B ykBC6+BClyʈ6 l+k] zʉPC6Oʩy^BC6 CBPz y zBCB 6ClyʙzBC7+BCPz ] C7z C B zk6 7zۙ]+ O ^ z+ yʉC 7k y ]+ +^ۉP 6]ۂ ] z C k C z] 6lC +zB+] zy ]k+ ^ z O 7C 6kCBC]zyz yzyz]BC PCz zyzCBCk+ ʹ6 C] B zB zyz^BC+ BzyzPC 7 C y kC + z ] ]+ 6 ] k C C B zB + ] B B zC + +z ] ]* zz B z6 ]k+ C6 ! C zP kC ] + z k+ + z] kC P z C y ^ B 6 C z 7kʹ]+ 7 C z ] yP BPBzzO O z +]ʹl7 + ]l+ ] + lBCPC 6 C z ]+] + z z C y* +O z B ]z k kzC zP+ CkzkB Bk B ]C z7+C ] z] y ^ Bz z Py 6]6 k+ Pz+ ] B ] Bz+! ^ 6y z* y l B6 C ] z P ! ] ] B 7 7 C By!B] B6 z C ]]C k+]6 6 z] 6 ] ] C6 kO C ] Cy lB6 z6 C+ 7 ]6 y ] 6 z 6 O+ z ] C] B y+ z CP 6zy CC lO Cz ]* z P y 6C7 Bz7 ]]6 z P B 6+ O6 ^ y ] + k C ۷ B7 B z ^ z z C ] 7+ z ^ 7 ] + B 7 Cy ]^ z BC ]] C P z O 6 ] C y ] k O C 7C y 6 7 ! z C +kCBy ] O + z C k + O C OB y C B y B k y O z l k BC B ]Cz P C k zB B B l y z ^O ^ C +B k l C z+ + C yCB P C z ! lz B 6 B C ] By z + zBB C ! Py z z C B C] CB 6 B z k6 zB BB y B y B ] O z+ C y B6 B z y zz7 y BCC ] z ^ O P C+ 6+ B C Cz* kyzyzyzylCBCBC z C CCz ] Pz 7 z Ck C B z zB C B 7 + z y 6 k Cl ] C B 6C zC zB B B C k z + z +z B 7+ C 6 B z C z C CB C O 7 6z 6 ] C yC C z ]B y l zB C C C k y ] y k C B l+ C ] ] Cz 6 O y B BBP P y + 6B ] O C C P Bz +kz yz yzyz yzyzyzyz z B CB z O ^ z O C z C C6 Bz + yC CB y 6z z z C C ] 7 B* B yk z z B B B z y B k z P ] ] C C z 6 yB C B z C +z O z z + C B z y B C Cz lC B z C B O +] B Cy zC B C yB Cz yz z + + B 7C z zB C B y+ z z zy l C]6Cz zy yCCB z y By y 6 O k C P 6 OC+ B ] PB y] y zC B Cy y C z] C+ B6 ] ByC zz BC B y z B z BC * ] + C6 ] B y C] y BB C z y C z B ^ ]+O] 6 z C C z 6 B yC CC y y Cy B y + z +y B y + y C B Cz y C z C z ] z *z Cz yB B C y k Cz Bz ! O O k 6 y Cz z B B C z C O y C z C Cyz z B y z z C C B z C y z B z P k + z y ] C y P y B C B z + zz ] z 6 +] y z C B y C zC BCz z yyO B ]] y7 zB y C C C z+ z z k C ]*!+ B ] z zz + zC ] y B CC z B z CCy6 *ۙ6 z z z z C B B yk z 6y P C]z]C+C z z y y BB B z O z ]z ! ] P + P z C z C C C z +] zB 6C k z C y yC CB y ! C z y k k k+y + + B z ] z 6 C z C CBy O 6y + z C +ll+ ]C y ^ y k z B B C z P k z C CB* 6Cz + ۢC y6 z 6 ] B C C y z ] ! ] P ܸ 6 ] ] P6z B C B B z O ] 6z 6 + ۡ C z P 6 B B B y O * z+ + 6ʩ z]B z 6 6 C y zy kC 6P*+ ۡ z ] C y z yk zy + * ] z y zy B y !+ z y ʠ ʸ ]y C+ C 7 C z y y + + + ] ] B ] y ^ z+ C+C* C + z z ]ʣ y y6 z ]6] z C z y + B O6 + C C ]6 y y 77^y * B P C k y l B l 6 7 z+ z+ k6 l B 76 ] k * O B C z + 6 6 k+ B 6 z k6 + y k +B B 6 + O 6 z 6 O * l O z6 ]] ] y ] ] P 6+ + ۳] y Ckl+ kz C l] ]67 C 6 + ] 7 B O ^ yO z]7y ] C 666 6ʣ k O+6 B 6kzC+ O l P] ] C P ] ʉB ]۷ C+ k k 6 ]+ + +]6 O^k Oz zyzy]CB Cz y۹zBC 6CPz C6 67 BB ʨy]B+CBz y + +B CzlC+ 6Pz k ]] + By B + B y ] C ]k CyP ] + *]k+ P ^ ] z ] kB6 *!!zC y C ] Py + O Cy C P B z+ z C Clz + C B] +6 O z] z7+z+ zl zC 6k 7B ] 6 l] +6 z ܧy!CBPzyz yz CBCB+6 P 6P P C Cz76C^zyz z yz yzyOCBC6 k+ 6 CBC]yzyz z yzykCBC*+P ]6 k ] +O B܈6 O C +kyC +Oۥ]+ CyP Bہ k ʨyPB* 6BkyPC+7Bk C+lʕʘyBC+CB]y۹z]BC +By Py O]z 6 ] ^ہ6 BC + 6 ] CPyz yzyz yz kC 6 6lۨl+ O z6C] ++6 z] 6 C 6 7 lz6 C ] 6y B z 7 l C] ہ B ] ]]C ] ہ C ] B C ] 6z C! CB l 7 B z +C C z P z* B P z B B P B B ] z ! + ]Bk^ ہ Oz ] ]+ y+ B ]C O Ck y k ] 7 7] + ] 7 ] ] z P ]B z] 6 6 zB6 ] y6 ^ ہ] O] y C 6kʨzCB C 7B 6CBCBCB ʁ ] ] + ʁ ] +ʁC ]B z+ +]CB]C +kʁl76zʁۘ]6 +Pzʹy ]CBCkzy
endstream
endobj
189 0 obj
<>/Filter/FlateDecode/Height 309/Length 29240/Name/X/Subtype/Image/Type/XObject/Width 987>>stream
H?Hi)B@HsPp#R$cHۜZZ%VVSeK<PX Ā"!!r70d>:S=3y۷}7b @Ҿ B<M3?2{ %ȣٜZ* JkӥZ nw;