%PDF-1.4 % 78 0 obj <> endobj 6 0 obj <>stream Acrobat Distiller 7.0 (Windows) 12th September 2019 0-00-00T00:00:02+19:00 2023-03-18T19:33:04-07:00 Arbortext Advanced Print Publisher 9.1.510/W Unicode 2023-03-18T19:33:04-07:00 application/pdf NEUROLOGY2019017905-WNL-D-19-00335 645..647 uuid:bb46ceeb-4003-4fb7-bfee-b2d0284b72d8 uuid:d6d54b1e-1dd1-11b2-0a00-380018d0bfff endstream endobj 21 0 obj <> endobj 10 0 obj <> endobj 11 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>> endobj 12 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>> endobj 13 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>> endobj 80 0 obj <>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/Type/Page>> endobj 87 0 obj [94 0 R 95 0 R 96 0 R 97 0 R] endobj 88 0 obj <>stream q 192 0 0 51 237 695 cm /Im0 Do Q BT /T1_0 1 Tf 12 0 0 12 236.50809 618.99991 Tm (DOI 10.1212/WNL.0000000000008186)Tj 7.749 1 Td (2019;93;647 )Tj /T1_1 1 Tf -4.47201 0 Td (Neurology\240)Tj /T1_2 1 Tf -4.11048 1.00001 Td (and recommendations from the IPMSSG)Tj -9.3345 1 Td (Clinical trials of disease-modifying agents in pediatric MS: Opportuniti\ es, challenges,)Tj ET BT /T1_2 1 Tf 12 0 0 12 198.17413 592 Tm (This information is current as of September 30, 2019)Tj ET 108 447 450 137 re 0 0 m S BT /T1_2 1 Tf 10 0 0 10 118 554.99997 Tm (Services)Tj 0 1 TD (Updated Information &)Tj ET BT /T1_0 1 Tf 10 0 0 10 454.22974 554.99997 Tm ( )Tj 0 0 1 rg -18.72297 0 Td (http://n.neurology.org/content/93/14/647.2.full)Tj 0 g T* (including high resolution figures, can be found at:)Tj ET BT /T1_2 1 Tf 10 0 0 10 118 532 Tm (References)Tj ET BT /T1_0 1 Tf 10 0 0 10 494.21951 521.99997 Tm ( )Tj 0 0 1 rg -22.72195 0 Td (http://n.neurology.org/content/93/14/647.2.full#ref-list-1)Tj 0 g T* (This article cites 1 articles, 1 of which you can access for free at: )Tj ET BT /T1_0 1 Tf 10 0 0 10 118 493.99997 Tm (\240 )Tj /T1_2 1 Tf T* (Permissions & Licensing)Tj ET BT /T1_0 1 Tf 10 0 0 10 524.7699 483.99994 Tm ( )Tj 0 0 1 rg -25.77699 0 Td (http://www.neurology.org/about/about_the_journal#permissions)Tj 0 g T* (its entirety can be found online at:)Tj 0 1.00001 TD (Information about reproducing this article in parts \(figures,tables\) o\ r in)Tj ET BT /T1_0 1 Tf 10 0 0 10 118 455.99997 Tm (\240 )Tj /T1_2 1 Tf 0 1 TD (Reprints)Tj ET BT /T1_0 1 Tf 10 0 0 10 441.4299 455.99997 Tm ( )Tj 0 0 1 rg -17.44299 0 Td (http://n.neurology.org/subscribers/advertise)Tj 0 g T* (Information about ordering reprints can be found online:)Tj ET 108 209 450 46 re 0 0 m S BT /T1_0 1 Tf 10 0 0 10 113 216.99994 Tm (rights reserved. 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