%PDF-1.4
%
76 0 obj
<>
endobj
77 0 obj
<>stream
Acrobat Distiller 7.0 (Windows)
21th August 2019
0-00-00T00:20:19+00:01
2023-10-01T03:32:20-07:00
Arbortext Advanced Print Publisher 9.1.510/W Unicode
2023-10-01T03:32:20-07:00
application/pdf
NEUROLOGY2018961383 487..499
uuid:1b8c4fa6-6a07-4e45-a050-3dba4bb54f80
uuid:cb1e34bd-1dd1-11b2-0a00-d3001813a5ff
21th August 2019
endstream
endobj
73 0 obj
<>
endobj
2 0 obj
<>
endobj
75 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
1 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
25 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
42 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
48 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
114 0 obj
<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/Type/Page>>
endobj
125 0 obj
[133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R 140 0 R 141 0 R]
endobj
126 0 obj
<>stream
q
192 0 0 51 236.5 695 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
12 0 0 12 236.00812 618.99991 Tm
(DOI 10.1212/WNL.0000000000008089)Tj
6.8325 1 Td
(2019;93;510-514 )Tj
/T1_1 1 Tf
-4.47201 0 Td
(Neurology\240)Tj
/T1_0 1 Tf
-6.55301 1.00001 Td
(Marissa Dean, Ludwine Messiaen, Gregory M. Cooper, et al. )Tj
/T1_2 1 Tf
25.42952 1 Td
( mutation)Tj
/T1_3 1 Tf
-3.16701 0 Td
(ADCY5)Tj
/T1_2 1 Tf
-27.36399 0 Td
(Child Neurology: Spastic paraparesis and dystonia with a novel )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 200.67416 592 Tm
(This information is current as of September 9, 2019)Tj
ET
108 319 449 265 re
0 0 m
S
BT
/T1_2 1 Tf
10 0 0 10 118 554.99997 Tm
(Services)Tj
0 1 TD
(Updated Information &)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 446.7298 554.99997 Tm
( )Tj
0 0 1 rg
-17.97298 0 Td
(http://n.neurology.org/content/93/11/510.full)Tj
0 g
T*
(including high resolution figures, can be found at:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 532 Tm
(References)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 486.71957 521.99997 Tm
( )Tj
0 0 1 rg
-21.97196 0 Td
(http://n.neurology.org/content/93/11/510.full#ref-list-1)Tj
0 g
T*
(This article cites 12 articles, 3 of which you can access for free at: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 504 Tm
(Subspecialty Collections)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 488.64996 393.99966 Tm
( )Tj
0 0 1 rg
-22.165 0 Td
(http://n.neurology.org/cgi/collection/spastic_paraplegia)Tj
0 g
/T1_2 1 Tf
T*
(Spastic paraplegia)Tj
/T1_0 1 Tf
18.167 1.00001 Td
( )Tj
0 0 1 rg
-18.167 0 Td
(http://n.neurology.org/cgi/collection/dystonia)Tj
0 g
/T1_2 1 Tf
T*
(Dystonia)Tj
/T1_0 1 Tf
19.77698 1 Td
( )Tj
0 0 1 rg
-19.77698 0 Td
(http://n.neurology.org/cgi/collection/all_pediatric)Tj
0 g
/T1_2 1 Tf
0 1.00001 TD
(All Pediatric)Tj
/T1_0 1 Tf
24.66599 1 Td
( )Tj
0 0 1 rg
-24.66599 0 Td
(http://n.neurology.org/cgi/collection/all_movement_disorders)Tj
0 g
/T1_2 1 Tf
0 1 TD
(All Movement Disorders)Tj
/T1_0 1 Tf
19.555 1 Td
( )Tj
0 0 1 rg
-19.555 0 Td
(http://n.neurology.org/cgi/collection/all_genetics)Tj
0 g
/T1_2 1 Tf
0 1.00001 TD
(All Genetics)Tj
/T1_0 1 Tf
0 1 TD
(following collection\(s\): )Tj
T*
(This article, along with others on similar topics, appears in the)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 365.99997 Tm
(\240 )Tj
/T1_2 1 Tf
T*
(Permissions & Licensing)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 524.76996 355.99994 Tm
( )Tj
0 0 1 rg
-25.777 0 Td
(http://www.neurology.org/about/about_the_journal#permissions)Tj
0 g
T*
(its entirety can be found online at:)Tj
0 1.00001 TD
(Information about reproducing this article in parts \(figures,tables\) o\
r in)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 327.99997 Tm
(\240 )Tj
/T1_2 1 Tf
0 1 TD
(Reprints)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 441.42996 327.99997 Tm
( )Tj
0 0 1 rg
-17.443 0 Td
(http://n.neurology.org/subscribers/advertise)Tj
0 g
T*
(Information about ordering reprints can be found online:)Tj
ET
108 209 449 46 re
0 0 m
S
BT
/T1_0 1 Tf
10 0 0 10 113 216.99994 Tm
(rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X.)Tj
T*
(1951, it is now a weekly with 48 issues per year. Copyright \251 2019 Am\
erican Academy of Neurology. All )Tj
4.47202 1.00001 Td
(\256 is the official journal of the American Academy of Neurology. Publi\
shed continuously since)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
ET
q
246.75 0 0 77.25 209.125 113.75 cm
-1 TL /Im1 Do
Q
endstream
endobj
131 0 obj
<>stream
y]Cz+z]zk+ y܉7 zۉ6+ k]z ʸykzCyzyz zPl + z y z y z zk k 6 z]C+ z]C6 7Oz ] ʁO 6ʩzO ]ʁ ]C yl ]ʁ C 6 ʹk k z 6 l k C ] ]]B + ۹ z 6 ʁz C k 6 z ] Bz ʻz ]y 6+ y z ] O z y y y y * z z ʾ B z + C z 6 yz ] z6z P6 z C z + By Bz Bz 7]z P zy6] ]y y CC y y B7 y z zy C zz ^ PB ! y y y BkyC+B C 7 B zz O+C C 7B zz ]] B^ O Czz ^CBCBCP B B C ] B z y 6 B y B6 z Cz y ] 6 B C zz 66 zl B C zy z C Czy BzBk C z y zy C ] + C zz CO z B6 7 C zz z y6 C+ BBz6 zy +P*z C ]CzC z z ] C* B k B ykBC6+BClyʈ6 l+k] zʉPC6Oʩy^BC6 CBPz y zBCB 6ClyʙzBC7+BCPz ] C7z C B zk6 7zۙ]+ O ^ z+ yʉC 7k y ]+ +^ۉP 6]ۂ ] z C k C z] 6lC +zB+] zy ]k+ ^ z O 7C 6kCBC]zyz yzyz]BC PCz zyzCBCk+ ʹ6 C] B zB zyz^BC+ BzyzPC 7 C y kC + z ] ]+ 6 ] k C C B zB + ] B B zC + +z ] ]* zz B z6 ]k+ C6 ! C zP kC ] + z k+ + z] kC P z C y ^ B 6 C z 7kʹ]+ 7 C z ] yP BPBzzO O z +]ʹl7 + ]l+ ] + lBCPC 6 C z ]+] + z z C y* +O z B ]z k kzC zP+ CkzkB Bk B ]C z7+C ] z] y ^ Bz z Py 6]6 k+ Pz+ ] B ] Bz+! ^ 6y z* y l B6 C ] z P ! ] ] B 7 7 C By!B] B6 z C ]]C k+]6 6 z] 6 ] ] C6 kO C ] Cy lB6 z6 C+ 7 ]6 y ] 6 z 6 O+ z ] C] B y+ z CP 6zy CC lO Cz ]* z P y 6C7 Bz7 ]]6 z P B 6+ O6 ^ y ] + k C ۷ B7 B z ^ z z C ] 7+ z ^ 7 ] + B 7 Cy ]^ z BC ]] C P z O 6 ] C y ] k O C 7C y 6 7 ! z C +kCBy ] O + z C k + O C OB y C B y B k y O z l k BC B ]Cz P C k zB B B l y z ^O ^ C +B k l C z+ + C yCB P C z ! lz B 6 B C ] By z + zBB C ! Py z z C B C] CB 6 B z k6 zB BB y B y B ] O z+ C y B6 B z y zz7 y BCC ] z ^ O P C+ 6+ B C Cz* kyzyzyzylCBCBC z C CCz ] Pz 7 z Ck C B z zB C B 7 + z y 6 k Cl ] C B 6C zC zB B B C k z + z +z B 7+ C 6 B z C z C CB C O 7 6z 6 ] C yC C z ]B y l zB C C C k y ] y k C B l+ C ] ] Cz 6 O y B BBP P y + 6B ] O C C P Bz +kz yz yzyz yzyzyzyz z B CB z O ^ z O C z C C6 Bz + yC CB y 6z z z C C ] 7 B* B yk z z B B B z y B k z P ] ] C C z 6 yB C B z C +z O z z + C B z y B C Cz lC B z C B O +] B Cy zC B C yB Cz yz z + + B 7C z zB C B y+ z z zy l C]6Cz zy yCCB z y By y 6 O k C P 6 OC+ B ] PB y] y zC B Cy y C z] C+ B6 ] ByC zz BC B y z B z BC * ] + C6 ] B y C] y BB C z y C z B ^ ]+O] 6 z C C z 6 B yC CC y y Cy B y + z +y B y + y C B Cz y C z C z ] z *z Cz yB B C y k Cz Bz ! O O k 6 y Cz z B B C z C O y C z C Cyz z B y z z C C B z C y z B z P k + z y ] C y P y B C B z + zz ] z 6 +] y z C B y C zC BCz z yyO B ]] y7 zB y C C C z+ z z k C ]*!+ B ] z zz + zC ] y B CC z B z CCy6 *ۙ6 z z z z C B B yk z 6y P C]z]C+C z z y y BB B z O z ]z ! ] P + P z C z C C C z +] zB 6C k z C y yC CB y ! C z y k k k+y + + B z ] z 6 C z C CBy O 6y + z C +ll+ ]C y ^ y k z B B C z P k z C CB* 6Cz + ۢC y6 z 6 ] B C C y z ] ! ] P ܸ 6 ] ] P6z B C B B z O ] 6z 6 + ۡ C z P 6 B B B y O * z+ + 6ʩ z]B z 6 6 C y zy kC 6P*+ ۡ z ] C y z yk zy + * ] z y zy B y !+ z y ʠ ʸ ]y C+ C 7 C z y y + + + ] ] B ] y ^ z+ C+C* C + z z ]ʣ y y6 z ]6] z C z y + B O6 + C C ]6 y y 77^y * B P C k y l B l 6 7 z+ z+ k6 l B 76 ] k * O B C z + 6 6 k+ B 6 z k6 + y k +B B 6 + O 6 z 6 O * l O z6 ]] ] y ] ] P 6+ + ۳] y Ckl+ kz C l] ]67 C 6 + ] 7 B O ^ yO z]7y ] C 666 6ʣ k O+6 B 6kzC+ O l P] ] C P ] ʉB ]۷ C+ k k 6 ]+ + +]6 O^k Oz zyzy]CB Cz y۹zBC 6CPz C6 67 BB ʨy]B+CBz y + +B CzlC+ 6Pz k ]] + By B + B y ] C ]k CyP ] + *]k+ P ^ ] z ] kB6 *!!zC y C ] Py + O Cy C P B z+ z C Clz + C B] +6 O z] z7+z+ zl zC 6k 7B ] 6 l] +6 z ܧy!CBPzyz yz CBCB+6 P 6P P C Cz76C^zyz z yz yzyOCBC6 k+ 6 CBC]yzyz z yzykCBC*+P ]6 k ] +O B܈6 O C +kyC +Oۥ]+ CyP Bہ k ʨyPB* 6BkyPC+7Bk C+lʕʘyBC+CB]y۹z]BC +By Py O]z 6 ] ^ہ6 BC + 6 ] CPyz yzyz yz kC 6 6lۨl+ O z6C] ++6 z] 6 C 6 7 lz6 C ] 6y B z 7 l C] ہ B ] ]]C ] ہ C ] B C ] 6z C! CB l 7 B z +C C z P z* B P z B B P B B ] z ! + ]Bk^ ہ Oz ] ]+ y+ B ]C O Ck y k ] 7 7] + ] 7 ] ] z P ]B z] 6 6 zB6 ] y6 ^ ہ] O] y C 6kʨzCB C 7B 6CBCBCB ʁ ] ] + ʁ ] +ʁC ]B z+ +]CB]C +kʁl76zʁۘ]6 +Pzʹy ]CBCkzy
endstream
endobj
132 0 obj
<>/Filter/FlateDecode/Height 309/Length 29240/Name/X/Subtype/Image/Type/XObject/Width 987>>stream
H?Hi)B@HsPp#R$cHۜZZ%VVSeK<PX Ā"!!r70d>:S=3y۷}7b @Ҿ B<M3?2{ %ȣٜZ* JkӥZ nw;