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January 16, 2018; 90 (3) Editorial

Silent cerebral infarction

Not so silent after all

Steven G. Pavlakis, E. Steve Roach
First published December 20, 2017, DOI: https://doi.org/10.1212/WNL.0000000000004839
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The occurrence of large cerebral infarctions due to sickle cell disease (SCD) has been known for many years, but it was not until 1988 that brain MRI documented 7 lesions consistent with subclinical infarction in 6 children with SCD who had experienced no prior signs or symptoms of stroke.1 Five of these 6 children had T2 hyperintensity abnormalities located in border zone regions. Such lesions were eventually characterized as a silent cerebral infarction (SCI). The presence of SCIs predicts both future SCIs and overt stroke.2

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  • Go to N.Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.

  • See page 115

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