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Editors' Note: In response to the article “Hand postures in primary and secondary generalized tonic-clonic seizures,” Dr. Mintzer explains why the statistical methodology employed by the authors, Fisher exact test with Bonferroni correction for multiple comparisons, was not ideal and that the version for multiple groups would have been preferable. He also reinforces a point brought up in a previous comment by Dr. Lanska: multiple events from the same patient should not be considered independent for the purpose of statistical analysis. Authors Siegel and Tatum describe how they addressed the problem statistically. Authors Uruha et al. report that the myxovirus resistance A (MxA) polyclonal antibodies used in their study, “Sarcoplasmic MxA expression: A valuable marker of dermatomyositis,” have been discontinued by the company that produced them. The authors describe the results of their tests into the company's monoclonal antibody alternative, concluding that the alternative can be used comparably to the original, but may require higher concentrations.—Megan Alcauskas, MD, and Robert C. Griggs, MD
Editors' Note: In response to the article “Hand postures in primary and secondary generalized tonic-clonic seizures,” Dr. Mintzer explains why the statistical methodology employed by the authors, Fisher exact test with Bonferroni correction for multiple comparisons, was not ideal and that the version for multiple groups would have been preferable.
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- © 2017 American Academy of Neurology
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