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I read with interest the article by Sundelin et al.,1 which looked at the risk of autism spectrum disorder (ASD) in individuals with epilepsy and in first-degree relatives. Epilepsy is more common in individuals with ASD and ASD is more common in individuals with childhood-onset epilepsy (and in their siblings and offspring), creating a “chicken or egg” situation: a situation in which it is impossible to say which of the 2 existed first and which caused the other one. The 2 conditions likely share common and yet undetermined genetic pathophysiologic mechanisms. It will be interesting to see the relationship between ASD and epilepsy in other patient population groups, such as India, where epilepsy is common, but not ASD.
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Author disclosures are available upon request (journal{at}neurology.org).
- © 2016 American Academy of Neurology
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