2016年9月6日
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临床特征的进化可能下文根据FP-CIT SPECT结果
Zuzana沃克,埃米利奥•莫雷诺,艾伦•托马斯,弗雷泽Inglis,纳吉·感觉,蒂姆·史蒂文斯,蒂姆·维特菲尔德,Dag Aarsland,迈克尔Rainer,亚历山德罗Padovani
第一次出版2016年8月10日,
DOI: https://doi.org/10.1212/WNL.0000000000003076
Zuzana沃克
来自伦敦大学学院(Z.W.);北埃塞克斯大学合作NHS信托基金会(Z.W.,t。s。,T.W.), Braintree; GE Healthcare (E.M.), Buckinghamshire; Newcastle University (A.T.), Newcastle upon Tyne; Glasgow Memory Clinic Ltd. (F.I.); Brighton and Sussex Medical School (N.T.), Brighton, UK; Centre for Age-Related Diseases (D.A.), Stavanger University Hospital; Department of Geriatric Psychiatry (D.A.), Akershus University Hospital, Oslo, Norway; Department of Neurobiology, (D.A.) Care Sciences and Society Division of Alzheimer's Disease Research Centre, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien (M.R.), Austria; and University of Brescia (A.P.), Italy.
医学博士
埃米利奥•莫雷诺
来自伦敦大学学院(Z.W.);北埃塞克斯大学合作NHS信托基金会(Z.W.,t。s。,T.W.), Braintree; GE Healthcare (E.M.), Buckinghamshire; Newcastle University (A.T.), Newcastle upon Tyne; Glasgow Memory Clinic Ltd. (F.I.); Brighton and Sussex Medical School (N.T.), Brighton, UK; Centre for Age-Related Diseases (D.A.), Stavanger University Hospital; Department of Geriatric Psychiatry (D.A.), Akershus University Hospital, Oslo, Norway; Department of Neurobiology, (D.A.) Care Sciences and Society Division of Alzheimer's Disease Research Centre, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien (M.R.), Austria; and University of Brescia (A.P.), Italy.
医学博士
艾伦•托马斯
来自伦敦大学学院(Z.W.);北埃塞克斯大学合作NHS信托基金会(Z.W.,t。s。,T.W.), Braintree; GE Healthcare (E.M.), Buckinghamshire; Newcastle University (A.T.), Newcastle upon Tyne; Glasgow Memory Clinic Ltd. (F.I.); Brighton and Sussex Medical School (N.T.), Brighton, UK; Centre for Age-Related Diseases (D.A.), Stavanger University Hospital; Department of Geriatric Psychiatry (D.A.), Akershus University Hospital, Oslo, Norway; Department of Neurobiology, (D.A.) Care Sciences and Society Division of Alzheimer's Disease Research Centre, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien (M.R.), Austria; and University of Brescia (A.P.), Italy.
医学博士
弗雷泽Inglis
来自伦敦大学学院(Z.W.);北埃塞克斯大学合作NHS信托基金会(Z.W.,t。s。,T.W.), Braintree; GE Healthcare (E.M.), Buckinghamshire; Newcastle University (A.T.), Newcastle upon Tyne; Glasgow Memory Clinic Ltd. (F.I.); Brighton and Sussex Medical School (N.T.), Brighton, UK; Centre for Age-Related Diseases (D.A.), Stavanger University Hospital; Department of Geriatric Psychiatry (D.A.), Akershus University Hospital, Oslo, Norway; Department of Neurobiology, (D.A.) Care Sciences and Society Division of Alzheimer's Disease Research Centre, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien (M.R.), Austria; and University of Brescia (A.P.), Italy.
医学博士
纳吉·感觉
来自伦敦大学学院(Z.W.);北埃塞克斯大学合作NHS信托基金会(Z.W.,t。s。,T.W.), Braintree; GE Healthcare (E.M.), Buckinghamshire; Newcastle University (A.T.), Newcastle upon Tyne; Glasgow Memory Clinic Ltd. (F.I.); Brighton and Sussex Medical School (N.T.), Brighton, UK; Centre for Age-Related Diseases (D.A.), Stavanger University Hospital; Department of Geriatric Psychiatry (D.A.), Akershus University Hospital, Oslo, Norway; Department of Neurobiology, (D.A.) Care Sciences and Society Division of Alzheimer's Disease Research Centre, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien (M.R.), Austria; and University of Brescia (A.P.), Italy.
医学博士
蒂姆·史蒂文斯
来自伦敦大学学院(Z.W.);北埃塞克斯大学合作NHS信托基金会(Z.W.,t。s。,T.W.), Braintree; GE Healthcare (E.M.), Buckinghamshire; Newcastle University (A.T.), Newcastle upon Tyne; Glasgow Memory Clinic Ltd. (F.I.); Brighton and Sussex Medical School (N.T.), Brighton, UK; Centre for Age-Related Diseases (D.A.), Stavanger University Hospital; Department of Geriatric Psychiatry (D.A.), Akershus University Hospital, Oslo, Norway; Department of Neurobiology, (D.A.) Care Sciences and Society Division of Alzheimer's Disease Research Centre, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien (M.R.), Austria; and University of Brescia (A.P.), Italy.
医学博士
蒂姆·维特菲尔德
来自伦敦大学学院(Z.W.);北埃塞克斯大学合作NHS信托基金会(Z.W.,t。s。,T.W.), Braintree; GE Healthcare (E.M.), Buckinghamshire; Newcastle University (A.T.), Newcastle upon Tyne; Glasgow Memory Clinic Ltd. (F.I.); Brighton and Sussex Medical School (N.T.), Brighton, UK; Centre for Age-Related Diseases (D.A.), Stavanger University Hospital; Department of Geriatric Psychiatry (D.A.), Akershus University Hospital, Oslo, Norway; Department of Neurobiology, (D.A.) Care Sciences and Society Division of Alzheimer's Disease Research Centre, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien (M.R.), Austria; and University of Brescia (A.P.), Italy.
MSc
Dag Aarsland
来自伦敦大学学院(Z.W.);北埃塞克斯大学合作NHS信托基金会(Z.W.,t。s。,T.W.), Braintree; GE Healthcare (E.M.), Buckinghamshire; Newcastle University (A.T.), Newcastle upon Tyne; Glasgow Memory Clinic Ltd. (F.I.); Brighton and Sussex Medical School (N.T.), Brighton, UK; Centre for Age-Related Diseases (D.A.), Stavanger University Hospital; Department of Geriatric Psychiatry (D.A.), Akershus University Hospital, Oslo, Norway; Department of Neurobiology, (D.A.) Care Sciences and Society Division of Alzheimer's Disease Research Centre, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien (M.R.), Austria; and University of Brescia (A.P.), Italy.
医学博士
迈克尔Rainer
来自伦敦大学学院(Z.W.);北埃塞克斯大学合作NHS信托基金会(Z.W.,t。s。,T.W.), Braintree; GE Healthcare (E.M.), Buckinghamshire; Newcastle University (A.T.), Newcastle upon Tyne; Glasgow Memory Clinic Ltd. (F.I.); Brighton and Sussex Medical School (N.T.), Brighton, UK; Centre for Age-Related Diseases (D.A.), Stavanger University Hospital; Department of Geriatric Psychiatry (D.A.), Akershus University Hospital, Oslo, Norway; Department of Neurobiology, (D.A.) Care Sciences and Society Division of Alzheimer's Disease Research Centre, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien (M.R.), Austria; and University of Brescia (A.P.), Italy.
医学博士
亚历山德罗Padovani
来自伦敦大学学院(Z.W.);北埃塞克斯大学合作NHS信托基金会(Z.W.,t。s。,T.W.), Braintree; GE Healthcare (E.M.), Buckinghamshire; Newcastle University (A.T.), Newcastle upon Tyne; Glasgow Memory Clinic Ltd. (F.I.); Brighton and Sussex Medical School (N.T.), Brighton, UK; Centre for Age-Related Diseases (D.A.), Stavanger University Hospital; Department of Geriatric Psychiatry (D.A.), Akershus University Hospital, Oslo, Norway; Department of Neurobiology, (D.A.) Care Sciences and Society Division of Alzheimer's Disease Research Centre, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien (M.R.), Austria; and University of Brescia (A.P.), Italy.
医学博士
文摘
摘要目的:来测试假设的核心和提示功能可能与路易体痴呆(下文将不同的能力来预测异常多巴胺转运体扫描,因此后续的诊断可能的下文。进一步的目标是评估患者的核心和提示功能的进化可能随着时间的推移下文根据123年I-FP-CIT SPECT扫描结果。
方法:共有187名患者可能下文(痴呆+ 1核心或一个提示功能)被随机的多巴胺转运体成像或后续没有扫描。下文特性比较基线和6个月随访根据成像结果和随访诊断。
结果:为整个群体,震颤麻痹的基准频率为30%,波动29%,视觉幻觉24%,REM睡眠行为障碍的17%。医生评分基线明显的震颤麻痹(p= 0.001)更频繁和统一帕金森病评定量表(UPDRS)评分明显高于基线(p= 0.02)患者异常的成像。UPDRS评分有显著增加的异常扫描组随时间(p< 0.01)。有相对较少的进化下文的其余部分功能无论成像结果。
结论:患者可能下文,除了UPDRS分数,没有下文的进化差异超过6个月临床特征之间的情况下正常和异常的成像。只有帕金森症和多巴胺转运蛋白显像有助于区分下文non-DLB痴呆。
术语表
- 下文=
- 路易体痴呆与;
- GDS=
- 老年抑郁量表;
- 患者的=
- 细微精神状态检查;
- MTA=
- 内侧颞叶萎缩;
- MTL=
- 内侧颞叶;
- RBD=
- REM睡眠行为障碍;
- UPDRS=
- 统一帕金森病评定量表
脚注
去首页Neurology.org为充分披露。资金信息和披露认为作者相关的,如果有的话,年底提供这篇文章。这篇文章由通用电气医疗集团支付加工费。
Coinvestigators列出在首页Neurology.org。
补充数据首页Neurology.org
- 收到了2015年9月4日。
- 接受的最终形式5月23日,2016年。
- ©2016美国神经病学学会的首页
这是一个开放的分布式根据文章Creative Commons Attribution-NonCommercial-NoDerivatives许可证4.0 (CC BY-NC-ND),它允许下载和共享工作提供适当的引用。工作不能以任何方式改变或商业使用。
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