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Unilateral pallidotomy has been accepted as an efficacious treatment for Parkinson disease (PD) compared with medical therapies.1 Currently, magnetic resonance–guided focused ultrasound (MRgFUS) has been developed as a minimally invasive surgical technique, generating precise thermal lesions in the brain.2,3 We report successful unilateral MRgFUS pallidotomy in a patient with PD to control not only levodopa-induced dyskinesia but also cardinal motor symptoms.
Acknowledgments
Acknowledgment: Itay Rachmilevitch and Eyal Zadicario, employees of InSightec (Haifa, Israel), provided technical assistance and description of methods.
Footnotes
Author contributions: Dr. Young Cheol Na contributed to patient selection, performed the baseline evaluation including medical and neurologic evaluation for study subjects, provided intraprocedural neurologic assessments, and wrote the first draft of the manuscript. Dr. Won Seok Chang designed the study, contributed towards patient selection, performed the procedures, and provided intraprocedural neurologic assessments. Dr. Jung designed the study. Eun Jung Kweon contributed to patient selection and performed the baseline evaluation including medical and neurologic evaluation for study subjects. Dr. Jin Woo Chang served as principal investigator and corresponding author, received research support from the Focused Ultrasound Foundation, designed the study, contributed towards patient selection, performed the procedures, and wrote the first draft of the manuscript.
Study funding: Sponsored by the Focused Ultrasound Foundation. The funder had no role in study design, data collection, decision to publish, or preparation of the manuscript.
Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- Received September 24, 2014.
- Accepted in final form April 8, 2015.
- © 2015 American Academy of Neurology
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