%PDF-1.7
%
46 0 obj
<>
endobj
146 0 obj
<>stream
Acrobat Distiller 7.0 (Windows)
D:00000000000020+05'00'
0-00-00T00:00:20+05:00
2023-08-04T05:35:47-07:00
Arbortext Advanced Print Publisher 9.1.510/W Unicode
2023-08-04T05:35:47-07:00
application/pdf
NEUROLOGY2015667717 2116..2125
uuid:26fed078-a81c-49f1-a48e-13ebfd20d26b
uuid:4a3069ed-1dd2-11b2-0a00-bf00883d9eff
14th November 2015
endstream
endobj
56 0 obj
<>
endobj
84 0 obj
<>
endobj
147 0 obj
<>
endobj
148 0 obj
<>
endobj
29 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
64 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
45 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
105 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
85 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
149 0 obj
<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/Type/Page>>
endobj
155 0 obj
[163 0 R 164 0 R 165 0 R 166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R]
endobj
156 0 obj
<>stream
q
192 0 0 51 237 695 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
12 0 0 12 236.50809 618.99991 Tm
(DOI 10.1212/WNL.0000000000002220)Tj
-3.83298 1 Td
(2015;85;2116-2125 Published Online before print November 18, 2015)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
/T1_0 1 Tf
3.93198 1.00001 Td
(Ilse Gijselinck, Sara Van Mossevelde, Julie van der Zee, et al. )Tj
/T1_2 1 Tf
0.98505 1 Td
( is a frequent cause of frontotemporal dementia in a Belgian cohort)Tj
/T1_3 1 Tf
-2.44501 0 Td
(TBK1)Tj
/T1_2 1 Tf
-3.27801 0 Td
(Loss of )Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 199.17609 592 Tm
(This information is current as of November 18, 2015)Tj
ET
108 281 450 303 re
0 0 m
S
BT
/T1_2 1 Tf
10 0 0 10 118 554.99997 Tm
(Services)Tj
0 1 TD
(Updated Information &)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 451.72974 554.99997 Tm
( )Tj
0 0 1 rg
-18.47297 0 Td
(http://n.neurology.org/content/85/24/2116.full)Tj
0 g
T*
(including high resolution figures, can be found at:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 532 Tm
(Supplementary Material)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 303.39005 471.99982 Tm
( )Tj
0 0 1 rg
-3.639 0 Td
(220.DC3)Tj
T*
(http://n.neurology.org/content/suppl/2016/07/22/WNL.0000000000002)Tj
0 g
3.639 1.00001 Td
( )Tj
0 0 1 rg
-3.639 0 Td
(220.DC2)Tj
T*
(http://n.neurology.org/content/suppl/2015/11/18/WNL.0000000000002)Tj
0 g
3.639 1 Td
( )Tj
0 0 1 rg
-3.639 0 Td
(220.DC1)Tj
0 1.00001 TD
(http://n.neurology.org/content/suppl/2015/11/18/WNL.0000000000002)Tj
0 g
0 1 TD
(Supplementary material can be found at: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 454 Tm
(References)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 491.71951 443.99997 Tm
( )Tj
0 0 1 rg
-22.47195 0 Td
(http://n.neurology.org/content/85/24/2116.full#ref-list-1)Tj
0 g
T*
(This article cites 39 articles, 11 of which you can access for free at: \
)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 426 Tm
(Subspecialty Collections)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 516.4296 355.99979 Tm
( )Tj
0 0 1 rg
-24.94296 0 Td
(http://n.neurology.org/cgi/collection/frontotemporal_dementia)Tj
0 g
/T1_2 1 Tf
T*
(Frontotemporal dementia)Tj
/T1_0 1 Tf
20.61099 1.00001 Td
( )Tj
0 0 1 rg
-20.61099 0 Td
(http://n.neurology.org/cgi/collection/cohort_studies)Tj
0 g
/T1_2 1 Tf
T*
(Cohort studies)Tj
/T1_0 1 Tf
19.55499 1 Td
( )Tj
0 0 1 rg
-19.55499 0 Td
(http://n.neurology.org/cgi/collection/all_genetics)Tj
0 g
/T1_2 1 Tf
0 1.00001 TD
(All Genetics)Tj
/T1_0 1 Tf
0 1 TD
(following collection\(s\): )Tj
T*
(This article, along with others on similar topics, appears in the)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 327.99997 Tm
(\240 )Tj
/T1_2 1 Tf
T*
(Permissions & Licensing)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 524.7699 317.99994 Tm
( )Tj
0 0 1 rg
-25.77699 0 Td
(http://www.neurology.org/about/about_the_journal#permissions)Tj
0 g
T*
(its entirety can be found online at:)Tj
0 1.00001 TD
(Information about reproducing this article in parts \(figures,tables\) o\
r in)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 289.99997 Tm
(\240 )Tj
/T1_2 1 Tf
0 1 TD
(Reprints)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 441.4299 289.99997 Tm
( )Tj
0 0 1 rg
-17.44299 0 Td
(http://n.neurology.org/subscribers/advertise)Tj
0 g
T*
(Information about ordering reprints can be found online:)Tj
ET
108 209 450 46 re
0 0 m
S
BT
/T1_0 1 Tf
10 0 0 10 113 216.99994 Tm
(rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X.)Tj
T*
(1951, it is now a weekly with 48 issues per year. Copyright \251 2015 Am\
erican Academy of Neurology. All )Tj
4.47202 1.00001 Td
(\256 is the official journal of the American Academy of Neurology. Publi\
shed continuously since)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
ET
q
246.75 0 0 77.25 209.625 113.75 cm
-1 TL /Im1 Do
Q
endstream
endobj
161 0 obj
<>stream
y]Cz+z]zk+ y܉7 zۉ6+ k]z ʸykzCyzyz zPl + z y z y z zk k 6 z]C+ z]C6 7Oz ] ʁO 6ʩzO ]ʁ ]C yl ]ʁ C 6 ʹk k z 6 l k C ] ]]B + ۹ z 6 ʁz C k 6 z ] Bz ʻz ]y 6+ y z ] O z y y y y * z z ʾ B z + C z 6 yz ] z6z P6 z C z + By Bz Bz 7]z P zy6] ]y y CC y y B7 y z zy C zz ^ PB ! y y y BkyC+B C 7 B zz O+C C 7B zz ]] B^ O Czz ^CBCBCP B B C ] B z y 6 B y B6 z Cz y ] 6 B C zz 66 zl B C zy z C Czy BzBk C z y zy C ] + C zz CO z B6 7 C zz z y6 C+ BBz6 zy +P*z C ]CzC z z ] C* B k B ykBC6+BClyʈ6 l+k] zʉPC6Oʩy^BC6 CBPz y zBCB 6ClyʙzBC7+BCPz ] C7z C B zk6 7zۙ]+ O ^ z+ yʉC 7k y ]+ +^ۉP 6]ۂ ] z C k C z] 6lC +zB+] zy ]k+ ^ z O 7C 6kCBC]zyz yzyz]BC PCz zyzCBCk+ ʹ6 C] B zB zyz^BC+ BzyzPC 7 C y kC + z ] ]+ 6 ] k C C B zB + ] B B zC + +z ] ]* zz B z6 ]k+ C6 ! C zP kC ] + z k+ + z] kC P z C y ^ B 6 C z 7kʹ]+ 7 C z ] yP BPBzzO O z +]ʹl7 + ]l+ ] + lBCPC 6 C z ]+] + z z C y* +O z B ]z k kzC zP+ CkzkB Bk B ]C z7+C ] z] y ^ Bz z Py 6]6 k+ Pz+ ] B ] Bz+! ^ 6y z* y l B6 C ] z P ! ] ] B 7 7 C By!B] B6 z C ]]C k+]6 6 z] 6 ] ] C6 kO C ] Cy lB6 z6 C+ 7 ]6 y ] 6 z 6 O+ z ] C] B y+ z CP 6zy CC lO Cz ]* z P y 6C7 Bz7 ]]6 z P B 6+ O6 ^ y ] + k C ۷ B7 B z ^ z z C ] 7+ z ^ 7 ] + B 7 Cy ]^ z BC ]] C P z O 6 ] C y ] k O C 7C y 6 7 ! z C +kCBy ] O + z C k + O C OB y C B y B k y O z l k BC B ]Cz P C k zB B B l y z ^O ^ C +B k l C z+ + C yCB P C z ! lz B 6 B C ] By z + zBB C ! Py z z C B C] CB 6 B z k6 zB BB y B y B ] O z+ C y B6 B z y zz7 y BCC ] z ^ O P C+ 6+ B C Cz* kyzyzyzylCBCBC z C CCz ] Pz 7 z Ck C B z zB C B 7 + z y 6 k Cl ] C B 6C zC zB B B C k z + z +z B 7+ C 6 B z C z C CB C O 7 6z 6 ] C yC C z ]B y l zB C C C k y ] y k C B l+ C ] ] Cz 6 O y B BBP P y + 6B ] O C C P Bz +kz yz yzyz yzyzyzyz z B CB z O ^ z O C z C C6 Bz + yC CB y 6z z z C C ] 7 B* B yk z z B B B z y B k z P ] ] C C z 6 yB C B z C +z O z z + C B z y B C Cz lC B z C B O +] B Cy zC B C yB Cz yz z + + B 7C z zB C B y+ z z zy l C]6Cz zy yCCB z y By y 6 O k C P 6 OC+ B ] PB y] y zC B Cy y C z] C+ B6 ] ByC zz BC B y z B z BC * ] + C6 ] B y C] y BB C z y C z B ^ ]+O] 6 z C C z 6 B yC CC y y Cy B y + z +y B y + y C B Cz y C z C z ] z *z Cz yB B C y k Cz Bz ! O O k 6 y Cz z B B C z C O y C z C Cyz z B y z z C C B z C y z B z P k + z y ] C y P y B C B z + zz ] z 6 +] y z C B y C zC BCz z yyO B ]] y7 zB y C C C z+ z z k C ]*!+ B ] z zz + zC ] y B CC z B z CCy6 *ۙ6 z z z z C B B yk z 6y P C]z]C+C z z y y BB B z O z ]z ! ] P + P z C z C C C z +] zB 6C k z C y yC CB y ! C z y k k k+y + + B z ] z 6 C z C CBy O 6y + z C +ll+ ]C y ^ y k z B B C z P k z C CB* 6Cz + ۢC y6 z 6 ] B C C y z ] ! ] P ܸ 6 ] ] P6z B C B B z O ] 6z 6 + ۡ C z P 6 B B B y O * z+ + 6ʩ z]B z 6 6 C y zy kC 6P*+ ۡ z ] C y z yk zy + * ] z y zy B y !+ z y ʠ ʸ ]y C+ C 7 C z y y + + + ] ] B ] y ^ z+ C+C* C + z z ]ʣ y y6 z ]6] z C z y + B O6 + C C ]6 y y 77^y * B P C k y l B l 6 7 z+ z+ k6 l B 76 ] k * O B C z + 6 6 k+ B 6 z k6 + y k +B B 6 + O 6 z 6 O * l O z6 ]] ] y ] ] P 6+ + ۳] y Ckl+ kz C l] ]67 C 6 + ] 7 B O ^ yO z]7y ] C 666 6ʣ k O+6 B 6kzC+ O l P] ] C P ] ʉB ]۷ C+ k k 6 ]+ + +]6 O^k Oz zyzy]CB Cz y۹zBC 6CPz C6 67 BB ʨy]B+CBz y + +B CzlC+ 6Pz k ]] + By B + B y ] C ]k CyP ] + *]k+ P ^ ] z ] kB6 *!!zC y C ] Py + O Cy C P B z+ z C Clz + C B] +6 O z] z7+z+ zl zC 6k 7B ] 6 l] +6 z ܧy!CBPzyz yz CBCB+6 P 6P P C Cz76C^zyz z yz yzyOCBC6 k+ 6 CBC]yzyz z yzykCBC*+P ]6 k ] +O B܈6 O C +kyC +Oۥ]+ CyP Bہ k ʨyPB* 6BkyPC+7Bk C+lʕʘyBC+CB]y۹z]BC +By Py O]z 6 ] ^ہ6 BC + 6 ] CPyz yzyz yz kC 6 6lۨl+ O z6C] ++6 z] 6 C 6 7 lz6 C ] 6y B z 7 l C] ہ B ] ]]C ] ہ C ] B C ] 6z C! CB l 7 B z +C C z P z* B P z B B P B B ] z ! + ]Bk^ ہ Oz ] ]+ y+ B ]C O Ck y k ] 7 7] + ] 7 ] ] z P ]B z] 6 6 zB6 ] y6 ^ ہ] O] y C 6kʨzCB C 7B 6CBCBCB ʁ ] ] + ʁ ] +ʁC ]B z+ +]CB]C +kʁl76zʁۘ]6 +Pzʹy ]CBCkzy
endstream
endobj
162 0 obj
<>/Filter/FlateDecode/Height 309/Length 29240/Name/X/Subtype/Image/Type/XObject/Width 987>>stream
H?Hi)B@HsPp#R$cHۜZZ%VVSeK<PX Ā"!!r70d>:S=3y۷}7b @Ҿ B<M3?2{ %ȣٜZ* JkӥZ nw;