%PDF-1.4
%
94 0 obj
<>
endobj
36 0 obj
<>stream
Acrobat Distiller 7.0 (Windows)
17th July 2014
2023-08-08T06:53:13-07:00
0-00-00T20:14:00Z
Arbortext Advanced Print Publisher 9.1.510/W Unicode
2023-08-08T06:53:13-07:00
application/pdf
NEUROLOGY2013546796 552..560
uuid:2b517fc6-0bc9-4abb-a89e-2cb01565d7a6
uuid:71d241db-1dd2-11b2-0a00-8800e84480ff
endstream
endobj
3 0 obj
<>
endobj
37 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC]/Properties<>/XObject<>>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
8 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
71 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
76 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
27 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
12 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
60 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
17 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
57 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[36 36 630 818.64]/Type/Page>>
endobj
103 0 obj
<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/Type/Page>>
endobj
114 0 obj
[121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R 130 0 R]
endobj
115 0 obj
<>stream
q
192 0 0 51 237 695 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
12 0 0 12 236.50809 618.99991 Tm
(DOI 10.1212/WNL.0000000000000673)Tj
-1.80599 1 Td
(2014;83;552-560 Published Online before print July 3, 2014)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
/T1_0 1 Tf
2.29251 1.00001 Td
(Laura J. Bonnett, Catrin Tudur Smith, Sarah Donegan, et al. )Tj
/T1_2 1 Tf
-0.72097 1 Td
(Treatment outcome after failure of a first antiepileptic drug)Tj
ET
BT
/T1_2 1 Tf
12 0 0 12 217.83005 592 Tm
(This information is current as of July 3, 2014)Tj
ET
108 301 450 283 re
0 0 m
S
BT
/T1_2 1 Tf
10 0 0 10 118 554.99997 Tm
(Services)Tj
0 1 TD
(Updated Information &)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 441.72974 554.99997 Tm
( )Tj
0 0 1 rg
-17.47297 0 Td
(http://n.neurology.org/content/83/6/552.full)Tj
0 g
T*
(including high resolution figures, can be found at:)Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 532 Tm
(Supplementary Material)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 303.39005 511.99994 Tm
( )Tj
0 0 1 rg
-3.639 0 Td
(673.DC1)Tj
T*
(http://n.neurology.org/content/suppl/2014/07/03/WNL.0000000000000)Tj
0 g
0 1.00001 TD
(Supplementary material can be found at: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 494 Tm
(References)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 481.71951 483.99997 Tm
( )Tj
0 0 1 rg
-21.47195 0 Td
(http://n.neurology.org/content/83/6/552.full#ref-list-1)Tj
0 g
0 1 TD
(This article cites 26 articles, 4 of which you can access for free at: )Tj
ET
BT
/T1_2 1 Tf
10 0 0 10 118 466 Tm
(Subspecialty Collections)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 453.66989 375.99973 Tm
( )Tj
0 0 1 rg
-18.66699 0 Td
(http://n.neurology.org/cgi/collection/prognosis)Tj
0 g
/T1_2 1 Tf
T*
(Prognosis)Tj
/T1_0 1 Tf
28.5 1.00001 Td
( )Tj
0 0 1 rg
-28.5 0 Td
(http://n.neurology.org/cgi/collection/natural_history_studies_prognosis)Tj
0 g
/T1_2 1 Tf
T*
(Natural history studies \(prognosis\))Tj
/T1_0 1 Tf
23.332 1 Td
( )Tj
0 0 1 rg
-23.332 0 Td
(http://n.neurology.org/cgi/collection/all_epilepsy_seizures)Tj
0 g
/T1_2 1 Tf
0 1.00001 TD
(All Epilepsy/Seizures)Tj
/T1_0 1 Tf
21.72198 1 Td
( )Tj
0 0 1 rg
-21.72198 0 Td
(http://n.neurology.org/cgi/collection/all_clinical_trials)Tj
0 g
/T1_2 1 Tf
0 1 TD
(All Clinical trials)Tj
/T1_0 1 Tf
T*
(following collection\(s\): )Tj
0 1.00001 TD
(This article, along with others on similar topics, appears in the)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 347.99997 Tm
(\240 )Tj
/T1_2 1 Tf
0 1 TD
(Permissions & Licensing)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 524.7699 337.99994 Tm
( )Tj
0 0 1 rg
-25.77699 0 Td
(http://www.neurology.org/about/about_the_journal#permissions)Tj
0 g
T*
(its entirety can be found online at:)Tj
0 1.00001 TD
(Information about reproducing this article in parts \(figures,tables\) o\
r in)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 118 309.99997 Tm
(\240 )Tj
/T1_2 1 Tf
0 1 TD
(Reprints)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 441.4299 309.99997 Tm
( )Tj
0 0 1 rg
-17.44299 0 Td
(http://n.neurology.org/subscribers/advertise)Tj
0 g
T*
(Information about ordering reprints can be found online:)Tj
ET
108 209 450 46 re
0 0 m
S
BT
/T1_0 1 Tf
10 0 0 10 113 216.99994 Tm
(rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X.)Tj
T*
(1951, it is now a weekly with 48 issues per year. Copyright \251 2014 Am\
erican Academy of Neurology. All )Tj
4.47202 1.00001 Td
(\256 is the official journal of the American Academy of Neurology. Publi\
shed continuously since)Tj
/T1_1 1 Tf
-4.47202 0 Td
(Neurology\240)Tj
ET
q
246.75 0 0 77.25 209.625 113.75 cm
-1 TL /Im1 Do
Q
endstream
endobj
119 0 obj
<>stream
y]Cz+z]zk+ y܉7 zۉ6+ k]z ʸykzCyzyz zPl + z y z y z zk k 6 z]C+ z]C6 7Oz ] ʁO 6ʩzO ]ʁ ]C yl ]ʁ C 6 ʹk k z 6 l k C ] ]]B + ۹ z 6 ʁz C k 6 z ] Bz ʻz ]y 6+ y z ] O z y y y y * z z ʾ B z + C z 6 yz ] z6z P6 z C z + By Bz Bz 7]z P zy6] ]y y CC y y B7 y z zy C zz ^ PB ! y y y BkyC+B C 7 B zz O+C C 7B zz ]] B^ O Czz ^CBCBCP B B C ] B z y 6 B y B6 z Cz y ] 6 B C zz 66 zl B C zy z C Czy BzBk C z y zy C ] + C zz CO z B6 7 C zz z y6 C+ BBz6 zy +P*z C ]CzC z z ] C* B k B ykBC6+BClyʈ6 l+k] zʉPC6Oʩy^BC6 CBPz y zBCB 6ClyʙzBC7+BCPz ] C7z C B zk6 7zۙ]+ O ^ z+ yʉC 7k y ]+ +^ۉP 6]ۂ ] z C k C z] 6lC +zB+] zy ]k+ ^ z O 7C 6kCBC]zyz yzyz]BC PCz zyzCBCk+ ʹ6 C] B zB zyz^BC+ BzyzPC 7 C y kC + z ] ]+ 6 ] k C C B zB + ] B B zC + +z ] ]* zz B z6 ]k+ C6 ! C zP kC ] + z k+ + z] kC P z C y ^ B 6 C z 7kʹ]+ 7 C z ] yP BPBzzO O z +]ʹl7 + ]l+ ] + lBCPC 6 C z ]+] + z z C y* +O z B ]z k kzC zP+ CkzkB Bk B ]C z7+C ] z] y ^ Bz z Py 6]6 k+ Pz+ ] B ] Bz+! ^ 6y z* y l B6 C ] z P ! ] ] B 7 7 C By!B] B6 z C ]]C k+]6 6 z] 6 ] ] C6 kO C ] Cy lB6 z6 C+ 7 ]6 y ] 6 z 6 O+ z ] C] B y+ z CP 6zy CC lO Cz ]* z P y 6C7 Bz7 ]]6 z P B 6+ O6 ^ y ] + k C ۷ B7 B z ^ z z C ] 7+ z ^ 7 ] + B 7 Cy ]^ z BC ]] C P z O 6 ] C y ] k O C 7C y 6 7 ! z C +kCBy ] O + z C k + O C OB y C B y B k y O z l k BC B ]Cz P C k zB B B l y z ^O ^ C +B k l C z+ + C yCB P C z ! lz B 6 B C ] By z + zBB C ! Py z z C B C] CB 6 B z k6 zB BB y B y B ] O z+ C y B6 B z y zz7 y BCC ] z ^ O P C+ 6+ B C Cz* kyzyzyzylCBCBC z C CCz ] Pz 7 z Ck C B z zB C B 7 + z y 6 k Cl ] C B 6C zC zB B B C k z + z +z B 7+ C 6 B z C z C CB C O 7 6z 6 ] C yC C z ]B y l zB C C C k y ] y k C B l+ C ] ] Cz 6 O y B BBP P y + 6B ] O C C P Bz +kz yz yzyz yzyzyzyz z B CB z O ^ z O C z C C6 Bz + yC CB y 6z z z C C ] 7 B* B yk z z B B B z y B k z P ] ] C C z 6 yB C B z C +z O z z + C B z y B C Cz lC B z C B O +] B Cy zC B C yB Cz yz z + + B 7C z zB C B y+ z z zy l C]6Cz zy yCCB z y By y 6 O k C P 6 OC+ B ] PB y] y zC B Cy y C z] C+ B6 ] ByC zz BC B y z B z BC * ] + C6 ] B y C] y BB C z y C z B ^ ]+O] 6 z C C z 6 B yC CC y y Cy B y + z +y B y + y C B Cz y C z C z ] z *z Cz yB B C y k Cz Bz ! O O k 6 y Cz z B B C z C O y C z C Cyz z B y z z C C B z C y z B z P k + z y ] C y P y B C B z + zz ] z 6 +] y z C B y C zC BCz z yyO B ]] y7 zB y C C C z+ z z k C ]*!+ B ] z zz + zC ] y B CC z B z CCy6 *ۙ6 z z z z C B B yk z 6y P C]z]C+C z z y y BB B z O z ]z ! ] P + P z C z C C C z +] zB 6C k z C y yC CB y ! C z y k k k+y + + B z ] z 6 C z C CBy O 6y + z C +ll+ ]C y ^ y k z B B C z P k z C CB* 6Cz + ۢC y6 z 6 ] B C C y z ] ! ] P ܸ 6 ] ] P6z B C B B z O ] 6z 6 + ۡ C z P 6 B B B y O * z+ + 6ʩ z]B z 6 6 C y zy kC 6P*+ ۡ z ] C y z yk zy + * ] z y zy B y !+ z y ʠ ʸ ]y C+ C 7 C z y y + + + ] ] B ] y ^ z+ C+C* C + z z ]ʣ y y6 z ]6] z C z y + B O6 + C C ]6 y y 77^y * B P C k y l B l 6 7 z+ z+ k6 l B 76 ] k * O B C z + 6 6 k+ B 6 z k6 + y k +B B 6 + O 6 z 6 O * l O z6 ]] ] y ] ] P 6+ + ۳] y Ckl+ kz C l] ]67 C 6 + ] 7 B O ^ yO z]7y ] C 666 6ʣ k O+6 B 6kzC+ O l P] ] C P ] ʉB ]۷ C+ k k 6 ]+ + +]6 O^k Oz zyzy]CB Cz y۹zBC 6CPz C6 67 BB ʨy]B+CBz y + +B CzlC+ 6Pz k ]] + By B + B y ] C ]k CyP ] + *]k+ P ^ ] z ] kB6 *!!zC y C ] Py + O Cy C P B z+ z C Clz + C B] +6 O z] z7+z+ zl zC 6k 7B ] 6 l] +6 z ܧy!CBPzyz yz CBCB+6 P 6P P C Cz76C^zyz z yz yzyOCBC6 k+ 6 CBC]yzyz z yzykCBC*+P ]6 k ] +O B܈6 O C +kyC +Oۥ]+ CyP Bہ k ʨyPB* 6BkyPC+7Bk C+lʕʘyBC+CB]y۹z]BC +By Py O]z 6 ] ^ہ6 BC + 6 ] CPyz yzyz yz kC 6 6lۨl+ O z6C] ++6 z] 6 C 6 7 lz6 C ] 6y B z 7 l C] ہ B ] ]]C ] ہ C ] B C ] 6z C! CB l 7 B z +C C z P z* B P z B B P B B ] z ! + ]Bk^ ہ Oz ] ]+ y+ B ]C O Ck y k ] 7 7] + ] 7 ] ] z P ]B z] 6 6 zB6 ] y6 ^ ہ] O] y C 6kʨzCB C 7B 6CBCBCB ʁ ] ] + ʁ ] +ʁC ]B z+ +]CB]C +kʁl76zʁۘ]6 +Pzʹy ]CBCkzy
endstream
endobj
120 0 obj
<>/Filter/FlateDecode/Height 309/Length 29240/Name/X/Subtype/Image/Type/XObject/Width 987>>stream
H?Hi)B@HsPp#R$cHۜZZ%VVSeK<PX Ā"!!r70d>:S=3y۷}7b @Ҿ B<M3?2{ %ȣٜZ* JkӥZ nw;