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Abstract
Objective: We wanted to investigate if retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) might be a good marker of acute and chronic changes in the afferent visual pathway following acute optic neuritis (ON).
Methods: We studied the relationship of optic nerve lesion length, optic nerve mean area, and RNFLT, quantified by OCT, with fMRI response to a visual paradigm in 40 patients with acute ON and 19 healthy controls in a prospective cohort study over a 6-month period.
Results: The main finding was a significant correlation of optic nerve lesion length and mean area with fMRI response in affected eyes in the acute phase and between RNFLT and fMRI response in affected eyes after recovery.
Conclusion: RNFLT is a very good measure of damage to the afferent visual pathway in recovered patients with ON and should be included in future fMRI studies when looking for visual reorganization in recovered patients with ON.
GLOSSARY
- BOLD=
- blood oxygenation level–dependent;
- FOV=
- field of view;
- HC=
- healthy control;
- OCT=
- optical coherence tomography;
- ON=
- optic neuritis;
- RNFLT=
- retinal nerve fiber layer thickness;
- ROI=
- region of interest;
- TE=
- echo time;
- TR=
- repetition time;
- VEP=
- visual evoked potential.
Footnotes
-
Study funding: This work was supported by Lundbeck Foundation via the Lundbeck Foundation Center for Neurovascular Signaling (LUCENS).
- Received November 23, 2010.
- Accepted April 20, 2011.
- Copyright © 2011 by AAN Enterprises, Inc.
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