视Neuromyelitis

Neuromyelitis视(动)是一个复发的炎症性疾病,其名称来自其突出的视神经和脊髓的苦难。¹一度被视为脱髓鞘变体的多发性硬化症(MS)、动现在是有原因地与特定疾病相关的自身抗体(NMO-immunoglobulin G(免疫球蛋白)),将有选择性地绑定到aquaporin-4 (AQP4)水通道,专门在星形胶质细胞在中枢神经系统的位置。²这种自身抗体的存在提出了问题的精确的角色产生动症状和病变。到目前为止,重点在动校正视力丧失和瘫痪等严重症状¹与著名相关病变的complement-mediated星形胶质细胞裂解构成或可能导致明显的炎症和组织破坏。^3,4

在这个问题上首页®,Popescu et al。⁵提供令人信服的证据表明,循环NMO-IgG(即。,autoantibodies to AQP4) mediate symptoms of nausea and vomiting in NMO without causing astrocyte loss or tissue destruction. They report 3 main findings. First, about 40% of a cohort of neuropathologic specimens from patients with NMO exhibited anatomic changes in the area postrema, whereas such changes were not found in control specimens …