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Anticonvulsants have been effective for tonic seizures of neuromyelitis optica (NMO) and multiple sclerosis (MS). Some anticonvulsants are immunosuppressants. It has been reported that carbamazepine (CBZ) administration lowers γ-globulin levels, presumably in connection with B cells.1 Neuromyelitis optica has specific anti-aquaporin-4 antibody (AQP4Ab) positivity; this is supported by the connection to antibody-mediated immunity. We report a case of a patient with NMO whose relapse of NMO was suppressed during secondary B lymphopenia.
Case report.
A 29-year-old woman gave birth to a boy in May 2003. In mid-July, she had weakness in her right upper limb, and weakness in all 4 extremities lasting 2 weeks. She was admitted to our hospital in August. Neurologic evaluation showed weakness of the neck and 4 extremities, exaggerated deep tendon reflexes in all 4 extremities, positive bilateral Babinski reflexes, and bilateral loss of sensation below the C2 level. She had dysuria and constipation. Expanded Disability Status Scale (EDSS) was 5.5. …
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