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There is considerable evidence that normal aging is associated with a decline in memory abilities. Memory decline is also among the earliest symptoms in a number of age-associated brain disorders, particularly Alzheimer disease (AD). Moreover, studies of subjects with mild cognitive impairments (MCI), a diagnostic concept for older individuals who cognitively lie between normal aging and dementia, established that memory deficits may develop many years before dementia can be diagnosed.1 The question therefore arises whether markers can be found that differentiate accurately between benign memory changes related to normal aging and those related to the earliest phase of AD.
For more than a decade, brain imaging studies, especially MRI, have provided valuable information about biologic correlates of cognitive deficits. The most relevant data along these lines involve studies of the hippocampus, the brain region most essential for normal memory. It is now well established that AD as well …
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