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To the Editor:
The article by Kim et al.1 provides evidence that progressive muscular atrophy (PMA) is a form of amyotrophic lateral sclerosis (ALS). The authors also cite pathologic data indicating that pyramidal tract degeneration is found in more than half of patients with PMA and that ubiquitinated inclusions can be seen in the surviving motor neurons of these patients.
A more sensitive and specific pathologic marker of ALS is TDP-43 immunostaining of motor neurons. TDP-43 inclusions are found in the motor neurons of all patients with ALS, except those with SOD1 or FUS mutations.2-4 We looked for …
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