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To the Editor:
I read the article by Aziz et al.1 with interest. The authors present a strong case for a hypermetabolic link between expanding CAG repeat number and the characteristic weight loss in Huntington disease (HD). It is notable that such recognized hypermetabolic disorders as thyrotoxicosis may also cause chorea. Perhaps therapeutic efforts to lower the metabolic rate by suppressing thyroid function should be investigated in patients with HD.
Disclosure: The author reports no disclosures.
Reply from the Authors:
We appreciate Dr. Gilbert's interest in our findings.1 The concept of suppressing thyroid function in HD in order to counteract weight loss is intriguing. In addition, …
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