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To the Editor:
I read the report by Bouilleret et al. with interest1 and request clarification on a few issues.
The first concerns the involvement of the substantia nigra. From the results of the SPM2 analyses depicted in figure 1, it appears from the position of the crosshairs in the [18F]fluoro-l-DOPA scan that the region distinguishing the patients is in the dorsal medial midbrain, perhaps corresponding to the periaqueductal gray region, whereas the substantia nigra is in the ventral midbrain and off the midline. Can the authors provide a more convincing image depicting decreased [18F]fluoro-l-DOPA-derived radioactivity in the substantia nigra of the patients?
The second is about the mechanism of decreased [18F]fluoro-l-DOPA-derived radioactivity in the basal ganglia. In 1988, we found …
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