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Diagnosis of essential tremor (ET) is based on clinical features.1 Presence of postural tremor (PT) is a requirement for the diagnosis of classic ET.1 Kinetic/intention tremor is present in most and resting tremor is seen in some patients with ET.1 The pathophysiology of ET remains unknown. One recent study reported significant cerebellar Purkinje cell (PC) loss in most ET cases and one autopsied patient revealed marked dentate nucleus neuronal loss.2 Since there is no suitable animal model of ET, observations in human subjects are critical to determine the pathophysiology of this disorder. The aim of this case report is to demonstrate transformation of classic ET to cerebellar ataxia and larger amplitude kinetic tremor but resolution of PT following ipsilateral cerebellar hemorrhage.
Case report.
A right-handed retired laboratory technologist with hypertension developed bilateral upper limb action tremor at age 30 years. The tremor progressed slowly but required no treatment. Family history revealed that her father had upper limb tremor and her 42-year-old daughter had ET onset at age 30 years. At age 65 she had spontaneous left cerebellar hemorrhage. Computerized …
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- CLASSIC ESSENTIAL TREMOR CHANGES FOLLOWING CEREBELLAR HEMORRHAGE
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