This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
In this issue of Neurology®, Bennett and others1 describe the clinical and electrophysiologic features, mode of inheritance, and lack of association with genes known to cause hereditary motor sensory neuropathy 2 (HMSN 2) (also called Charcot Marie Tooth 2 [CMT 2]). Six kindreds with inherited axonal polyneuropathy of late onset are described. The disorder was inherited as an autosomal dominant trait in two and by unknown transmission in the other four. The authors conclude that these are late onset forms of inherited axonal neuropathies and that “the genetic causes remain unknown and genetic heterogeneity… is likely.”
Recognizing that specific treatment is not available for HMSN (1, 2, or other), should neurologists be interested in these descriptions? I suggest four reasons. First, it is new medical information. True, many of us have previously encountered many patients with HMSN 2 who had late symptomatic onset, but putative genes were not excluded. Whether late onset will remain a characteristic feature will need to be ascertained later.
The second reason is that the studies provide further scientific evidence of genetic heterogeneity …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
- Late-onset HMSN 2: Further evidence of genetic heterogeneity
- Reply from the author
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Topics Discussed
Alert Me
Recommended articles
Ulcero-mutilating neuropathy in an Austrian kinship without linkage to hereditary motor and sensory neuropathy IIB and hereditary sensory neuropathy I loci
Axonal Charcot-Marie-Tooth disease
Autosomal dominant spastic paraplegia with peripheral neuropathy maps to chr12q23-24
Late-onset hereditary axonal neuropathies