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To the Editor:
We read the article by Alonso et al. with interest.1 They conclude that the initiation of antigout medication is associated with a lower risk of developing Parkinson disease (PD).
We have determined an association with serum uric acid (UA) in neurodegenerative disorders such as PD, amyotrophic lateral sclerosis, and Alzheimer disease. In our research of 100 cases with PD, there are no significant differences in the serum level of patients with PD and controls. Correlation coefficients in the PD group showed no significant relationships between the variable age, sex, duration, and clinical characteristics of PD. There is no past history of gout in our patients with PD. UA is a product of purine metabolism in mammals. UA is an important natural antioxidant and acts as a scavenger of free radicals.2
We would like the authors to clarify several points. First, were all patients with high levels of UA treated with antigout …
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