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Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset
This study confirms an unequivocal association between Parkinson disease and heterozygous Gaucher disease–causing GBA mutations. Moreover, a genotype-phenotype correlation between different GBA mutations and disease risk and age at motor symptom onset was demonstrated, suggesting that the identification of high-risk “severe” GBA mutation carriers may allow for closer clinical follow-up.
See p. 2277; Editorial, p. 2272
Precipitating factors of somnambulism: Impact of sleep deprivation and forced arousals
This paper provides a protocol to establish an objectively based diagnosis …
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