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To the Editor:
We read the article by Kantarci et al. with great interest. It examined the sex-specific association of APOE polymorphisms with disease severity in multiple sclerosis (MS).1 Sex specificity is important and has not been previously addressed. We recently analyzed and described APOE polymorphisms in relation to MS susceptibility, disease characteristics (including age at onset and onset type), disease severity (progression index, time to reach Expanded Disability Status Scale [EDSS] 6), and MRI findings (lesion volumes and atrophy measures) in a cohort of 408 MS patients, but did not focus on sex specificity.2
In an attempt to validate the findings by Kantarci et al., we re-analyzed our data applying similar methods. Our cohort included 250 women and 158 men, mean age at onset (± SD) 32.3 ± 9.5 years, mean disease duration 13.4 ± 8.0 years, median time to EDSS 6 9.2 (IQR 5.4 to 14.0) years, and 39% relapsing remitting, 39% secondary progressive, and 22% primary progressive. Genotype …
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