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To the Editor:
We read with interest the study of Wilson et al.1 describing an association between proneness to psychological distress and Alzheimer disease (AD). Whereas the findings are of interest, the main conclusion of the article is not supported by the evidence. The data may justify drawing an association between psychological distress and the risk of developing dementia, but they refute the conclusion that the risk of AD is greater, since no association was found in the subgroup of 140 demented persons who were found to have definite AD by standard research criteria.2 The authors state, “distress proneness was not associated with AD pathology.”1
It has been …
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