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Abstract
Quinacrine has been reported as an antiprion agent and proposed as an immediately applicable treatment for Creutzfeldt–Jakob disease (CJD). The authors report the results of an open compassionate procedure to which 32 CJD patients had access. In some genotypic subgroups, a slight but nonsignificant increase in survival was observed, likely due to biased inclusion of long-term surviving patients. There was no pathologic evidence of a beneficial effect of quinacrine treatment.
- Received June 30, 2004.
- Accepted in final form August 13, 2004.
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Letters: Rapid online correspondence
- Reply to Benito-León
- Compassionate use of quinacrine in Creutzfeldt–Jakob disease fails to show significant effects
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