This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Polioviruses (and other enteroviruses) have long been considered a possible cause of ALS because these viruses and ALS share the same pathologic target, the motor neuron. 1 In addition, an increased frequency of ALS has been reported to occur in patients with previous poliomyelitis. 2However, these epidemiological reports remain controversial 3 and may relate to earlier confusion with the syndrome of late weakness and atrophy that occurs after poliomyelitis, 4 post-polio syndrome. Since it is now recognized that persistent poliovirus and other enterovirus infections occur in animals, immunodeficient humans, and cell culture systems, it remains important to examine viruses as causative agents of ALS. 1
Over the last 30 years, there have been many attempts to find viruses in ALS tissues. These studies have included antibody assays, standard viral isolation techniques, and electron microscopy for viral particles, and all have been uniformly negative. 5 …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Topics Discussed
Alert Me
Recommended articles
Failure to detect enterovirus in the spinal cord of ALS patients using a sensitive RT-PCR method
Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS
Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis
April 27 Highlights