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To the Editor:
Ishida et al.1 report a case of sporadic Creutzfeldt-Jakob disease (sCJD) characterized by homozygosity for methionine at codon 129 of the prion protein gene (PRNP) and type 1 PrPres associated with focal plaque-like deposits in the brain. They report that these deposits were mainly in the cerebellar cortex, while the cerebral cortex showed mostly diffuse, synaptic type PrP immunoreactivity. The immunoblot analysis was performed only on homogenates from the frontal cortex.
We previously found the co-occurrence of focal and synaptic PrP immunoreactivity in the same subject, both in different brain regions and within the same region.2 In each, we demonstrated the presence of both type 1 and type 2 PrPres in the brain, with a strict relation …
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