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Multiple system atrophy (MSA) is a sporadic neurodegenerative disease that is difficult to diagnose. MRI can show signal abnormalities such as putaminal hyperintensity, hyperintense putaminal rim, and significant putaminal hypointensity, strengthening a diagnosis of MSA.1–7⇓⇓⇓⇓⇓⇓ However, these abnormalities are highly variable among the published cases and reports.1–7⇓⇓⇓⇓⇓⇓ Differences of magnetic field strengths and sequences and pathologic features could explain such variability of putaminal signal changes, but the precise nature of putaminal signal changes remains unclear.1–7⇓⇓⇓⇓⇓⇓
We report an MRI study of the cadaveric tissue from a patient with MSA performed to investigate putaminal signal changes with different magnetic field strengths and then correlated the findings with histopathologic observations.
Case report.
A 54-year-old man first noticed gait disturbance at age 48 years and dysuria and erectile dysfunction at age 49 years, all of which steadily worsened. Neurologic examinations at age 50 years revealed urinary dysfunction and parkinsonism poorly responsive …
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