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Enteroviral RNA sequences were identified in spinal cords from 15 of 17 patients with ALS using reverse transcriptase PCR (RT-PCR).1 PCR products were localized in neuronal cell bodies within the gray matter by direct RT in situ PCR.1 A previous study reported enteroviral RNA sequences in spinal cords from 8 of 11 patients with ALS.2 We report a patient with ALS treated with pleconaril, an antienteroviral drug.3
Case report.
A 76-year-old man noticed dyspnea and exercise limitation in October 1996. He had polio at age 3 affecting the right leg. Chest x-rays and CT showed atelectasis. Cardiac evaluation was negative. He had carbon dioxide retention (pCO2 50 mm Hg). Forced vital capacity (FVC), forced expiratory volume (FEV1), maximum voluntary ventilation (MVV), and total lung capacity were reduced, whereas FEV1/FVC was normal. Negative inspiratory pressure was 30 cm H2O standing and sitting and 15 cm H2O when lying flat. Expiratory pressure was 60 cm H2O. He was started on albuterol and home bilevel …
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