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Abstract
The reason for differences in rate of cognitive decline in AD is unknown. The interleukin-1 α (IL-1α) −889 *2 allele is associated with increased risk for AD. Surprisingly, in a sample of 114 patients followed for an average of 3.8 years, individuals homozygous for the IL-1α −889 *1 allele declined significantly more rapidly on the Mini-Mental State Examination than did others. There was no difference in rate of decline between patients with and without the APOEε4 allele. These results support the hypothesis that inflammation is important in the clinical course of AD.
- Received September 15, 2000.
- Accepted February 15, 2001.
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