Lamotrigine adjunctive therapy in painful phenomena in MS: Preliminary observations
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Several types of painful phenomena may occur in MS, including burning paresthesias, pain in the extremities (paroxysmal or constant), and painful tonic spasms (PTS). These are particularly disturbing and often difficult to treat.
Lamotrigine (LTG), a new antiepileptic drug, has been found to be effective against the paroxysmal pain of trigeminal neuralgia.1,2 We performed an open add-on study to assess whether LTG could also improve burning paresthesias, pain, and PTS in MS patients who were not responding to maximum doses of drugs that are usually effective.
Patients.
The cohort included 21 patients (16 female, 5 male) treated at the MS Regional Center in Cagliari, Italy. All had definite MS according to the criteria of Poser et al.3 Twelve had relapsing-remitting MS, 7 secondary progressive, and 2 primary progressive. Fifteen patients reported pain or burning paresthesias in the extremities (paroxysmal in 9 and continuous in 6), and …
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