Clinical Companion to the Molecular and Genetic Basis of Neurological Disease, 2nd Edition
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edited by R.N. Rosenberg, S.B. Prusiner, S. DiMauro, and R.L. Barchi, 318 pp., ill., Boston, MA, Butterworth-Heinemann, 1998, $45.00
The Molecular and Genetic Basis of Neurological Disease in its second edition is quite a formidable text. Written by a cast of 129 authors, its 1,429 pages are presented in 77 chapters grouped into 23 sections. Edited by 4 highly regarded neurologists—Drs. Rosenberg, Prusiner, DiMauro, and Barchi—it is probably the premier reference volume in its field. The book echoes the remarkable developments in the field of molecular neurogenetics of the last decade. In fact, in the vast majority of inherited neurologic disorders, the responsible gene has been cloned and the protein identified. This is the first major step in the development of pharmacologic and gene therapy intervention strategies.
One problem with such a large and comprehensive volume is that it is unlikely to be used to any great extent by many neurologists or primary care physicians who care for patients with neurogenetic disorders. This is where the Clinical Companion is an ideal compromise. As the editors point out, the Companion can be used as a quick reference, stand-alone text, or concise review, when the original volume is used as a primary text.
The handbook has 23 chapters corresponding to the 23 sections in the original. The authors have successfully taken the most useful practical and clinical information and put it into condensed form. For more detailed discussion, the reader is referred to the appropriate chapters in the larger volume.
This Clinical Companion is a great idea. It is delightful to read as it gives a succinct overview of neurogenetic diseases from a clinical, a biochemical, and a molecular perspective. I recommend it highly to all neurologists as well as other physicians who care for patients with neurologic disease.
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